Dr. Soma Chattopadhyay

Academics

Degree	University/Institution
M.Sc. in Zoology	University of Calcutta
Ph.D. (Molecular Virology of Human Rotaviruses)	University of Calcutta [National Institute of Cholera and Enteric Diseases (NICED), Kolkata]

Work Experience

Position	University/Organisation	Period
Scientist F	Institute of Life Sciences, Bhubaneswar-751023, India.	Since July 2021
Scientist E	Institute of Life Sciences, Bhubaneswar-751023, India.	July 2017 to June 2021
Scientist D	Institute of Life Sciences, Bhubaneswar-751023, India.	July 2013 to June 2017
Scientist C	Institute of Life Sciences, Bhubaneswar-751023, India.	October 2007 to June 2013
Post-Doctoral Fellowship	University of Connecticut Health Center, Farmington, USA.	2003-2007
Senior Research Fellowship	CSIR	2001-2003
Junior Research Fellowship	ICMR (National Institute of Cholera & Enteric Diseases, Kolkata)	2001
Junior Research Fellowship	DBT (National Institute of Cholera & Enteric Diseases, Kolkata)	1998-2001

Awards & Recognition

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Life member, Society of Biological Chemists (India). Life member, Indian Virological Society Life member, Proteomics society of India

Research

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Molecular Virology Broad Research Interest: Molecular virology: Viral replication, Virus-Cell interactions, Pathogenesis of Viral infection, Regulation of Viral Infection Research projects Chikungunya Infection: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes a disease syndrome characterized by fever, headache, rash, nausea, vomiting, myalgia and arthralgia. According to the posture developed as a result of the arthritic symptoms of the disease the name is derived from the Makonde word meaning “that which bends up”. The disease was first described in 1952 in Tanzania, Africa and is geographically distributed from Africa through Southeast Asia and South America. After a gap of 32 years, re-emergence of Chikungunya virus caused recent outbreaks in India during 2005-2006 affecting 1.3 million people in 13 states. Due to recent extension around the Indian Ocean, including Comoros, Mauritius, Reunion Island, Madagascar and now in Italy, Chikungunya is regarded as a potential worldwide public health problem with no preventive or therapeutic means available. This establishes the need to improve disease surveillance, study the pathogenesis and biology of the virus. The alpha viruses are enveloped particles and their genome consists of a linear, single- stranded, positive sense RNA molecule of approximately 11.8 kb. CHIK V genome encodes four non-structural proteins (NSP1-4) and three main structural proteins (C, E1, and E2). The non-structural proteins which are generally required for viral replication are encoded in the 5’ two-third of the genome. These proteins might have some role in modulating the host protein synthesis for the advantage of the viral infection as well as for pathogenesis or virulence. Due to lack of research on the Chikungunya viral biology the precise role of the non-structural proteins and the host factors are not yet understood. The knowledge about viral replication and host cell factors will be useful to understand the process of disease progression and find out ways to develop an effective antiviral therapy. Thus, my laboratory is working on the following topics : Define the functions of the non-structural proteins of Chikungunya virus during replication. Understand the structure-function relationship of important viral enzymes which can be target for antiviral drugs. Identify the cellular proteins required for viral life cycle. Understand the molecular mechanism of disease progression and identify the pathogenic marker to modulate the disease developed by Chikungunya.

Details

Molecular Virology

Broad Research Interest: Molecular virology: Viral replication, Virus-Cell interactions, Pathogenesis of Viral infection, Regulation of Viral Infection

Research projects

Chikungunya Infection:

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes a disease syndrome characterized by fever, headache, rash, nausea, vomiting, myalgia and arthralgia. According to the posture developed as a result of the arthritic symptoms of the disease the name is derived from the Makonde word meaning “that which bends up”.

The disease was first described in 1952 in Tanzania, Africa and is geographically distributed from Africa through Southeast Asia and South America. After a gap of 32 years, re-emergence of Chikungunya virus caused recent outbreaks in India during 2005-2006 affecting 1.3 million people in 13 states. Due to recent extension around the Indian Ocean, including Comoros, Mauritius, Reunion Island, Madagascar and now in Italy, Chikungunya is regarded as a potential worldwide public health problem with no preventive or therapeutic means available. This establishes the need to improve disease surveillance, study the pathogenesis and biology of the virus.

The alpha viruses are enveloped particles and their genome consists of a linear, single- stranded, positive sense RNA molecule of approximately 11.8 kb. CHIK V genome encodes four non-structural proteins (NSP1-4) and three main structural proteins (C, E1, and E2). The non-structural proteins which are generally required for viral replication are encoded in the 5’ two-third of the genome. These proteins might have some role in modulating the host protein synthesis for the advantage of the viral infection as well as for pathogenesis or virulence.

Due to lack of research on the Chikungunya viral biology the precise role of the non-structural proteins and the host factors are not yet understood. The knowledge about viral replication and host cell factors will be useful to understand the process of disease progression and find out ways to develop an effective antiviral therapy.

Thus, my laboratory is working on the following topics :

Define the functions of the non-structural proteins of Chikungunya virus during replication.
Understand the structure-function relationship of important viral enzymes which can be target for antiviral drugs.
Identify the cellular proteins required for viral life cycle.
Understand the molecular mechanism of disease progression and identify the pathogenic marker to modulate the disease developed by Chikungunya.

Publications

Details
Publications: 2024 Dash, R. N., Prabhudutta, M., De, S., Swain, R. P., Moharana, A. K., Subudhi, B. B., & Chattopadhyay, S. (2024). Conjugates of ibuprofen inhibit CHIKV infection and inflammation. Molecular diversity Mamidi, P., Panda, S., Ray, A., Mohanty, M., Mandal, M. C., Santra, D., Moharana, B., Nayak, B., Chattopadhyay, S., & Mishra, B. (2024). *Molecular characterization of coxsackievirus A24 variants isolated from an outbreak of acute hemorrhagic conjunctivitis. Indian journal of medical microbiology* 2023 Dash, R. N., Ray, A., Mamidi, P., De, S., Mohapatra, T. K., Moharana, A. K., Mukherjee, T., Ghosh, S., Chattopadhyay, S., Subudhi, B. B., & Chattopadhyay, S. (2023). Salicylic Acid Conjugate of Telmisartan Inhibits Chikungunya Virus Infection and Inflammation. ACS omega Chatterjee, S., Subudhi, B. B., & Chattopadhyay, S. (2023). A hidden gem Catenin-α-1 is essential for Chikungunya virus infection. Microbiology spectrum Chatterjee, S., Ghosh, S., Datey, A., Mahish, C., Chattopadhyay, S., & Chattopadhyay, S. (2023). Chikungunya virus perturbs the Wnt/β-catenin signaling pathway for efficient viral infection. Journal of virology Babu, N., Mahilkar, S., Jayaram, A., Ibemgbo, S. A., Mathur, G., Shetty, U., Sudandiradas, R., Kumar, P. S., Singh, S., Pani, S. S., Mudgal, P. P., Shastri, J. S., Agarwal, S., Ratho, P. K., Mishra, B., Chattopadhyay, S., Jagadesh, A., & Sunil, S. (2023). Cytokine profile, neutralisation potential and viral replication dynamics in sera of chikungunya patients in India: a cross-sectional study. The Lancet regional health – Southeast Asia Halder, S., Thakur, A., Keshry, S. S., Jana, P., Karothia, D., Das Jana, I., Acevedo, O., Swain, R. K., Mondal, A., Chattopadhyay, S., Jayaprakash, V., & Dev, A. (2023). SELEX based aptamers with diagnostic and entry inhibitor therapeutic potential for SARS-CoV-2. *Scientific reports* Sengupta, S., Shaw, S. K., Chatterjee, S., Bhattacharya, G., Barik, P. K., Chattopadhyay, S., & Devadas, S. (2023). Perturbations in spike-specific peripheral T follicular helper cells in SARS-CoV2 breakthrough convalescent individuals immunized by BBV152 vaccine. *Journal of medical virology* Mahish, C., De, S., Chatterjee, S., Ghosh, S., Keshry, S. S., Mukherjee, T., Khamaru, S., Tung, K. S., Subudhi, B. B., Chattopadhyay, S., & Chattopadhyay, S. (2023). TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages. *Frontiers in immunology* Kode, J., Maharana, J., Dar, A. A., Mukherjee, S., Gadewal, N., Sigalapalli, D. K., Kumar, S., Panda, D., Ghosh, S., Keshry, S. S., Mamidi, P., Chattopadhyay, S., Pradhan, T., Kailaje, V., Inamdar, S., & Gujjarwar, V. (2023). 6-Shogaol Exhibits Anti-viral and Anti-inflammatory Activity in COVID-19-Associated Inflammation by Regulating NLRP3 Inflammasomes. *ACS omega* 2022 Chatterjee, S., Kumar, S., Mamidi, P., Datey, A., Sengupta, S., Mahish, C., Laha, E., De, S., Keshry, S. S., Nayak, T. K., Ghosh, S., Singh, S., Subudhi, B. B., Chattopadhyay, S., & Chattopadhyay, S. (2022). DNA Damage Response Signaling Is Crucial for Effective Chikungunya Virus Replication. *Journal of virology* Chatterjee, S., Keshry, S. S., Ghosh, S., Ray, A., & Chattopadhyay, S ^#. (2022). Versatile β-Catenin Is Crucial for SARS-CoV-2 Infection. Microbiology spectrum De S, Ghosh S, Keshry SS, Mahish C, Mohapatra C, Guru A, Mamidi P, Datey A, Pani SS, Vasudevan D, Beuria TK, Chattopadhyay S, Subudhi BB ^#, Chattopadhyay S ^#. MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo. Antimicrobial Agents and Chemotherapy. 2022 Singh B, Avula K, Chatterjee S, Datey A, Ghosh A, De S, Keshry SS, Ghosh S, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Prasad P, Raghav S, Swain R, Parida A, Hussain Syed G ^#, Chattopadhyay S ^#. Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India. Frontiers in Microbiology. 2022 Simo Nemg FB, De S, Keshry SS, Mamidi P, Njayou FN, Demanou M, Moundipa Fewou P ^#, Chattopadhyay S ^#. Plants extracts from Cameroon pharmacopeia strongly inhibit the Chikungunya virus infection by targeting entry and replication steps. Journal of Ethnopharmacology. 2022 Prasad P^#, Mahapatra S, Mishra R, Murmu KC, Aggarwal S, Sethi M, Mohapatra P, Ghosh A, Yadav R, Dodia H, Ansari SA, De S, Singh D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Chattopadhyay S, Syed GH, Swain R, Raghav SK, Parida A ^#. *Long-read 16S-seq reveals nasopharynx microbial dysbiosis and enrichment of Mycobacterium* and Mycoplasma in COVID-19 patients: a potential source of co-infection. Molecular Omics. 2022 Sengupta S, Bhattacharya G, Chatterjee S, Datey A, Shaw SK, Suranjika S, Nath P, Barik PK, Prasad P, Chattopadhyay S, Swain RK, Parida A ^#, Devadas S ^#. Underlying Co-Morbidity Reveals Unique Immune Signatures in Type II Diabetes Patients Infected With SARS-CoV2. Frontiers in Immunology. 2022 Panda S K, Mishra S, Mamidi P, Chattopadhyay S, Singh A K ^#. An efficient PET-based probe for detection and discrimination of Zn2+ and Cd2+ in near-aqueous media and live-cell imaging. Journal of Photochemistry and Photobiology A: Chemistry. 2022 De S, Mamidi P, Ghosh S, Keshry SS, Mahish C, Pani SS, Laha E, Ray A, Datey A, Chatterjee S, Singh S, Mukherjee T, Khamaru S, Chattopadhyay S ^#, Subudhi BB ^#, Chattopadhyay S ^#. Telmisartan Restricts Chikungunya Virus Infection In Vitro and In Vivo through the AT1/PPAR-γ/MAPKs Pathways. Antimicrobial Agents and Chemotherapy. 2022 2021 Chatterjee S, Datey A, Sengupta S, Ghosh A, Jha A, Walia S, Singh S, Suranjika S, Bhattacharya G, Laha E, Keshry SS, Ray A, Pani SS, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Syed GH, Prasad P, Raghav SK, Devadas S, Swain RK, Chattopadhyay S, Parida A. Clinical, Virological, Immunological, and Genomic Characterization of Asymptomatic and Symptomatic Cases With SARS-CoV-2 Infection in India. Frontiers in Cellular and Infection Microbiology. 2021 Mamidi P, Nayak TK, Kumar A, Kumar S, Chatterjee S, De S, Datey A, Ghosh S, Keshry SS, Singh S, Laha E, Ray A, Chattopadhyay S, Chattopadhyay S. MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway. PLoS Pathogens. 2021 Nath P, Chauhan NR, Jena KK, Datey A, Kumar ND, Mehto S, De S, Nayak TK, Priyadarsini S, Rout K, Bal R, Murmu KC, Kalia M, Patnaik S, Prasad P, Reggiori F, Chattopadhyay S, Chauhan S. Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses. EMBO Reports. 2021 Kumar A, De S, Moharana AK, Nayak TK, Saswat T, Datey A, Mamidi P, Mishra P, Subudhi BB, Chattopadhyay S. Inhibition of herpes simplex virus-1 infection by MBZM-N-IBT: in silico and in vitro studies. Virology Journal. 2021 2020 Hossain S, Prakash V, Mamidi P, Chattopadhyay S, Singh A. Pyrene Appended Bipyridine Hydrazone Ligand as a Turn-ON Sensor for Cu2+ and Its Bioimaging Application. RSC Advances. 2020 Datey A, Singh LM, Rajkhowa U, Prusty BK, Saswat T, Mamidi P, Barkalita LM, Dutta R, Sharma KC, Sahoo D, Borah P, Devi SI, Chattopadhyay S. Molecular epidemiology of Japanese encephalitis virus in pig population of Odisha, Assam and Manipur states of India. Infection, Genetics and Evolution. 2020 Sanjai Kumar P, Nayak TK, Mahish C, Sahoo SS, Radhakrishnan A, De S, Datey A, Sahu RP, Goswami C, Chattopadhyay S, Chattopadhyay S. Inhibition of transient receptor potential vanilloid 1 (TRPV1) channel regulates chikungunya virus infection in macrophages. Archives of Virology. 2020 Jena KK, Mehto S, Nath P, Chauhan NR, Sahu R, Dhar K, Das SK, Kolapalli SP, Murmu KC, Jain A, Krishna S, Sahoo BS, Chattopadhyay S, Rusten TE, Prasad P, Chauhan S, Chauhan S. Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response. EMBO Reports. 2020 Raghav S, Ghosh A, Turuk J, Kumar S, Jha A, Madhulika S, Priyadarshini M, Biswas VK, Shyamli PS, Singh B, Singh N, Singh D, Datey A, Avula K, Smita S, Sabat J, Bhattacharya D, Kshatri JS, Vasudevan D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Swain R, Chattopadhyay S, Syed GH, Dixit A, Prasad P; Odisha COVID-19 Study Group; ILS COVID-19 Team, Pati S, Parida A. Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity. Frontiers in Microbiology. 2020 2019 Dey D, Siddiqui SI, Mamidi P, Ghosh S, Kumar CS, Chattopadhyay S, Ghosh S, Banerjee M. The effect of amantadine on an ion channel protein from Chikungunyavirus. PLOS Neglected Tropical Diseases. 2019 Nayak TK, Mamidi P, Sahoo SS, Kumar PS, Mahish C, Chatterjee S, Subudhi BB, Chattopadhyay S, Chattopadhyay S. P38 and JNK Mitogen-Activated Protein Kinases Interact with Chikungunya Virus Non-Structural Protein-2 and Regulate TNF Induction during Viral Infection in Macrophages*. Frontiers in Immunology. 2019 Saswat T, Sahoo N, Muduli S, Debata NK, Chattopadhyay S, Chattopadhyay S. Epidemiological trends and molecular dynamics of dengue, chikungunya virus infection, coinfection, and other undifferentiated fever during 2015-2016 in Odisha, India. Journal of Medical Virology. 2019 Patro ARK, Mohanty S, Prusty BK, Singh DK, Gaikwad S, Saswat T, Chattopadhyay S, Das BK, Tripathy R, Ravindran B. Cytokine Signature Associated with Disease Severity in Dengue.* *Viruses. 2019 2018* Kumar S, Kumar A, Mamidi P, Tiwari A, Kumar S, Mayavannan A, Mudulli S, Singh AK, Subudhi BB, Chattopadhyay S. Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity. *Scientific Reports. 2018 2017* Nayak TK, Mamidi P, Kumar A, Singh LP, Sahoo SS, Chattopadhyay S, Chattopadhyay S. Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages. *Viruses. 2017 2016* Mishra P, Kumar A, Mamidi P, Kumar S, Basantray I, Saswat T, Das I, Nayak TK, Subhasis Chattopadhyay S, Subudhi BB, Chattopadhyay S. Inhibition of Chikungunya Virus Replication by 1-[(2-Methylbenzimidazol-1-yl) Methyl]-2-Oxo Indolin-3-ylidene] Amino] Thiourea (MBZM-N-IBT). *Scientific Reports.2016 2015* Kumar S, Mamidi P, Kumar A, Basantray I, Bramha U, Dixit A, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S, Chattopadhyay S. Development of novel antibodies against non-structural proteins nsP1, nsP3 and nsP4 of Chikungunya virus: Potential use in basic research. *Archives of Virology. 2015 Saswat T, Kumar A, Kumar S, Mamidi P, Muduli S, Debata NK, Pal NS, Pratheek BM., Chattopadhyay S, Chattopadhyay S. High rates of co-infection of Dengue and Chikungunya virus in Odisha and Maharashtra, India during 2013. Infection, Genetics and Evolution. 2015 Pratheek BM, Suryawanshi AR, Chattopadhyay S, Chattopadhyay S. In silico analysis of MHC-I restricted epitopes of Chikungunya virus proteins: Implication in understanding anti-CHIKV CD8(+) T cell response and advancement of epitope based immunotherapy for CHIKV infection. Infection, Genetics and Evolution. 2015 2014* Chattopadhyay S, Kumar A, Mamidi P, Nayak TK, Das I, Chhatai J, Basantray I, Bramha U, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S. Development and characterization of monoclonal antibody against non-structural protein-2 of Chikungunya virus and its application. *Journal of Virological Methods. 2014 Kumar A, Mamidi P, Das I, Nayak TK, Kumar S, Chhatai J, Chattopadhyay S, Suryawanshi AR, Chattopadhyay S. A novel 2006 Indian outbreak strain of Chikungunya virus exhibits different pattern of infection as compared to prototype strain. PLOS One. 2014 Das I, Basantray I, Mamidi P, Nayak TK, B M P, Chattopadhyay S, Chattopadhyay S. Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection. PLOS One. 2014 2007* Chattopadhyay S, Weller SK. Direct interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer. Journal of Virology. 2007 2006 Chattopadhyay S, Weller SK. DNA binding activity of the herpes simplex virus type 1 origin binding protein, UL9, can be modulated by sequences in the N terminus: correlation between transdominance and DNA binding. Journal of Virology. 2006 Varghese V, Ghosh S, Das S, Bhattacharya SK, Krishnan T, Karmakar P, Kobayashi N, Naik TN. Characterization of VP1, VP2 and VP3 gene segments of a human rotavirus closely related to porcine strains. *Virus Genes. 2006 2005* Chaudhuri S, Das S, Chowdhury A, Santra A, Bhattacharya SK, Naik TN. Molecular epidemiology of HCV infection among acute and chronic liver disease patients in Kolkata, India. Journal of Clinical Virology. 2005 2004 Das S, Varghese V, Chaudhuri S, Barman P, Kojima K, Dutta P, Bhattacharya SK, Krishnan T, Kobayashi N, Naik TN. Genetic variability of human rotavirus strains isolated from Eastern and Northern India. Journal of Medical Virology. 2004 Barman P, Ghosh S, Das S, Varghese V, Chaudhuri S, Sarkar S, Krishnan T, Bhattacharya SK, Chakrabarti A, Kobayashi N, Naik TN. Sequencing and sequence analysis of VP7 and NSP5 genes reveal emergence of a new genotype of bovine group B rotaviruses in India. *Journal of Clinical Microbiology. 2004 Varghese V, Das S, Singh NB, Kojima K, Bhattacharya SK, Krishnan T, Kobayashi N, Naik TN. Molecular characterization of a human rotavirus reveals porcine characteristics in most of the genes including VP6 and NSP4. Archives of Virology. 2004 2003* Das S, Varghese V, Chaudhury S, Barman P, Mahapatra S, Kojima K, Bhattacharya SK, Krishnan T, Ratho RK, Chhotray GP, Phukan AC, Kobayashi N, Naik TN. Emergence of novel human group A rotavirus G12 strains in India. *Journal of Clinical Microbiology. 2003 2002* Das S, Sen A, Uma G, Varghese V, Chaudhuri S, Bhattacharya SK, Krishnan T, Dutta P, Dutta D, Bhattacharya MK, Mitra U, Kobayashi N, Naik TN. Genomic diversity of group A rotavirus strains infecting humans in eastern India. *Journal of Clinical Microbiology. 2002 2001* Sen A, Kobayashi N, Das S, Krishnan T, Bhattacharya SK, Naik TN. The evolution of human group B rotaviruses. *The Lancet. 2001 2000* Sen A, Kobayashi N, Das S, Krishnan T, Bhattacharya SK, Urasawa S, Naik TN. Amplification of various genes of human group B rotavirus from stool specimens by RT-PCR. Journal of Clinical Virology. 2000 1999 Krishnan T, Sen A, Choudhury JS, Das S, Naik TN, Bhattacharya SK. Emergence of adult diarrhoea rotavirus in Calcutta, India. The Lancet. 1999 Review articles: Kumar, P. S., Radhakrishnan, A., Mukherjee, T., Khamaru, S., Chattopadhyay, S., & Chattopadhyay, S. (2022). Understanding the role of Ca²⁺ via transient receptor potential (TRP) channel in viral infection: Implications in developing future antiviral strategies. *Virus research* Subudhi BB, Chattopadhyay S, Chattopadhyay S. Targeting host factors of virus-induced inflammation: a strategy for tackling future epidemics by RNA viruses. *Future Virology. 2022 Translational Research Consortia (TRC) for Chikungunya Virus in India. Current Status of Chikungunya in India. Frontiers in Microbiology. 2021 Subudhi BB, Chattopadhyay S, Mishra P, Kumar A. Current Strategies for Inhibition of Chikungunya Infection. Viruses. 2018 Pratheek BM, Nayak TK, Sahoo SS, Mohanty PK, Chattopadhyay S, Chakraborty NG, Chattopadhyay S. Mammalian non-classical major histocompatibility complex I and its receptors: Important contexts of gene, evolution, and immunity. Indian Journal of Human Genetics. 2014 Pratheek BM, Saha S, Maiti PK, Chattopadhyay S, Chattopadhyay S. Immune regulation and evasion of Mammalian host cell immunity during viral infection. Indian Journal of Virology. 2013 Chattopadhyay S, Chen Y, Weller SK. The two helicases of herpes simplex virus type 1 (HSV-1). Frontiers in Bioscience. 2006 Patents filed/granted:* Granted: Patent No.: 347450; Priority Date: 12.12.2014; Grant date:19.09.2020. Chattopadhyay S, Kumar A, Subudhi BB, Mishra P. A composition for inhibition of infection caused by Chikungunya virus (CHIKV). Filed: Application No.: 202031033920. BB Subudhi, R N Dash, Alok Kumar Moharana, P Mamidi, S Chattopadhyay. Anti-CHIKV Ibuprofen conjugates and method of preparation thereof. Filing date: 07/08/2020. Application No.: 201931012926. BB Subudhi, R N Dash, T K Mohapatra, P Mamidi, S Chattopadhyay. Antiviral Drug Conjugate Composition. Filing Date: 30/03/2019.

Details

Publications:

2024

Dash, R. N., Prabhudutta, M., De, S., Swain, R. P., Moharana, A. K., Subudhi, B. B., & Chattopadhyay, S. (2024). Conjugates of ibuprofen inhibit CHIKV infection and inflammation. Molecular diversity
Mamidi, P., Panda, S., Ray, A., Mohanty, M., Mandal, M. C., Santra, D., Moharana, B., Nayak, B., Chattopadhyay, S., & Mishra, B. (2024). Molecular characterization of coxsackievirus A24 variants isolated from an outbreak of acute hemorrhagic conjunctivitis. Indian journal of medical microbiology

2023

Dash, R. N., Ray, A., Mamidi, P., De, S., Mohapatra, T. K., Moharana, A. K., Mukherjee, T., Ghosh, S., Chattopadhyay, S., Subudhi, B. B., & Chattopadhyay, S. (2023). Salicylic Acid Conjugate of Telmisartan Inhibits Chikungunya Virus Infection and Inflammation. ACS omega
Chatterjee, S., Subudhi, B. B., & Chattopadhyay, S. (2023). A hidden gem Catenin-α-1 is essential for Chikungunya virus infection. Microbiology spectrum
Chatterjee, S., Ghosh, S., Datey, A., Mahish, C., Chattopadhyay, S., & Chattopadhyay, S. (2023). Chikungunya virus perturbs the Wnt/β-catenin signaling pathway for efficient viral infection. Journal of virology
Babu, N., Mahilkar, S., Jayaram, A., Ibemgbo, S. A., Mathur, G., Shetty, U., Sudandiradas, R., Kumar, P. S., Singh, S., Pani, S. S., Mudgal, P. P., Shastri, J. S., Agarwal, S., Ratho, P. K., Mishra, B., Chattopadhyay, S., Jagadesh, A., & Sunil, S. (2023). Cytokine profile, neutralisation potential and viral replication dynamics in sera of chikungunya patients in India: a cross-sectional study. The Lancet regional health – Southeast Asia
Halder, S., Thakur, A., Keshry, S. S., Jana, P., Karothia, D., Das Jana, I., Acevedo, O., Swain, R. K., Mondal, A., Chattopadhyay, S., Jayaprakash, V., & Dev, A. (2023). SELEX based aptamers with diagnostic and entry inhibitor therapeutic potential for SARS-CoV-2. Scientific reports
Sengupta, S., Shaw, S. K., Chatterjee, S., Bhattacharya, G., Barik, P. K., Chattopadhyay, S., & Devadas, S. (2023). Perturbations in spike-specific peripheral T follicular helper cells in SARS-CoV2 breakthrough convalescent individuals immunized by BBV152 vaccine. Journal of medical virology
Mahish, C., De, S., Chatterjee, S., Ghosh, S., Keshry, S. S., Mukherjee, T., Khamaru, S., Tung, K. S., Subudhi, B. B., Chattopadhyay, S., & Chattopadhyay, S. (2023). TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages. Frontiers in immunology
Kode, J., Maharana, J., Dar, A. A., Mukherjee, S., Gadewal, N., Sigalapalli, D. K., Kumar, S., Panda, D., Ghosh, S., Keshry, S. S., Mamidi, P., Chattopadhyay, S., Pradhan, T., Kailaje, V., Inamdar, S., & Gujjarwar, V. (2023). 6-Shogaol Exhibits Anti-viral and Anti-inflammatory Activity in COVID-19-Associated Inflammation by Regulating NLRP3 Inflammasomes. ACS omega

2022

Chatterjee, S., Kumar, S., Mamidi, P., Datey, A., Sengupta, S., Mahish, C., Laha, E., De, S., Keshry, S. S., Nayak, T. K., Ghosh, S., Singh, S., Subudhi, B. B., Chattopadhyay, S., & Chattopadhyay, S. (2022). DNA Damage Response Signaling Is Crucial for Effective Chikungunya Virus Replication. Journal of virology
Chatterjee, S., Keshry, S. S., Ghosh, S., Ray, A., & Chattopadhyay, S ^#. (2022). Versatile β-Catenin Is Crucial for SARS-CoV-2 Infection. Microbiology spectrum
De S, Ghosh S, Keshry SS, Mahish C, Mohapatra C, Guru A, Mamidi P, Datey A, Pani SS, Vasudevan D, Beuria TK, Chattopadhyay S, Subudhi BB ^#, Chattopadhyay S ^#. MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo. Antimicrobial Agents and Chemotherapy. 2022
Singh B, Avula K, Chatterjee S, Datey A, Ghosh A, De S, Keshry SS, Ghosh S, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Prasad P, Raghav S, Swain R, Parida A, Hussain Syed G ^#, Chattopadhyay S ^#. Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India. Frontiers in Microbiology. 2022
Simo Nemg FB, De S, Keshry SS, Mamidi P, Njayou FN, Demanou M, Moundipa Fewou P ^#, Chattopadhyay S ^#. Plants extracts from Cameroon pharmacopeia strongly inhibit the Chikungunya virus infection by targeting entry and replication steps. Journal of Ethnopharmacology. 2022
Prasad P^#, Mahapatra S, Mishra R, Murmu KC, Aggarwal S, Sethi M, Mohapatra P, Ghosh A, Yadav R, Dodia H, Ansari SA, De S, Singh D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Chattopadhyay S, Syed GH, Swain R, Raghav SK, Parida A ^#. Long-read 16S-seq reveals nasopharynx microbial dysbiosis and enrichment of Mycobacterium and Mycoplasma in COVID-19 patients: a potential source of co-infection. Molecular Omics. 2022
Sengupta S, Bhattacharya G, Chatterjee S, Datey A, Shaw SK, Suranjika S, Nath P, Barik PK, Prasad P, Chattopadhyay S, Swain RK, Parida A ^#, Devadas S ^#. Underlying Co-Morbidity Reveals Unique Immune Signatures in Type II Diabetes Patients Infected With SARS-CoV2. Frontiers in Immunology. 2022
Panda S K, Mishra S, Mamidi P, Chattopadhyay S, Singh A K ^#. An efficient PET-based probe for detection and discrimination of Zn2+ and Cd2+ in near-aqueous media and live-cell imaging. Journal of Photochemistry and Photobiology A: Chemistry. 2022
De S, Mamidi P, Ghosh S, Keshry SS, Mahish C, Pani SS, Laha E, Ray A, Datey A, Chatterjee S, Singh S, Mukherjee T, Khamaru S, Chattopadhyay S ^#, Subudhi BB ^#, Chattopadhyay S ^#. Telmisartan Restricts Chikungunya Virus Infection In Vitro and In Vivo through the AT1/PPAR-γ/MAPKs Pathways. Antimicrobial Agents and Chemotherapy. 2022

2021

Chatterjee S, Datey A, Sengupta S, Ghosh A, Jha A, Walia S, Singh S, Suranjika S, Bhattacharya G, Laha E, Keshry SS, Ray A, Pani SS, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Syed GH, Prasad P, Raghav SK, Devadas S, Swain RK, Chattopadhyay S, Parida A. Clinical, Virological, Immunological, and Genomic Characterization of Asymptomatic and Symptomatic Cases With SARS-CoV-2 Infection in India. Frontiers in Cellular and Infection Microbiology. 2021
Mamidi P, Nayak TK, Kumar A, Kumar S, Chatterjee S, De S, Datey A, Ghosh S, Keshry SS, Singh S, Laha E, Ray A, Chattopadhyay S, Chattopadhyay S. MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway. PLoS Pathogens. 2021
Nath P, Chauhan NR, Jena KK, Datey A, Kumar ND, Mehto S, De S, Nayak TK, Priyadarsini S, Rout K, Bal R, Murmu KC, Kalia M, Patnaik S, Prasad P, Reggiori F, Chattopadhyay S, Chauhan S. Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses. EMBO Reports. 2021
Kumar A, De S, Moharana AK, Nayak TK, Saswat T, Datey A, Mamidi P, Mishra P, Subudhi BB, Chattopadhyay S. Inhibition of herpes simplex virus-1 infection by MBZM-N-IBT: in silico and in vitro studies. Virology Journal. 2021

2020

Hossain S, Prakash V, Mamidi P, Chattopadhyay S, Singh A. Pyrene Appended Bipyridine Hydrazone Ligand as a Turn-ON Sensor for Cu2+ and Its Bioimaging Application. RSC Advances. 2020
Datey A, Singh LM, Rajkhowa U, Prusty BK, Saswat T, Mamidi P, Barkalita LM, Dutta R, Sharma KC, Sahoo D, Borah P, Devi SI, Chattopadhyay S. Molecular epidemiology of Japanese encephalitis virus in pig population of Odisha, Assam and Manipur states of India. Infection, Genetics and Evolution. 2020
Sanjai Kumar P, Nayak TK, Mahish C, Sahoo SS, Radhakrishnan A, De S, Datey A, Sahu RP, Goswami C, Chattopadhyay S, Chattopadhyay S. Inhibition of transient receptor potential vanilloid 1 (TRPV1) channel regulates chikungunya virus infection in macrophages. Archives of Virology. 2020
Jena KK, Mehto S, Nath P, Chauhan NR, Sahu R, Dhar K, Das SK, Kolapalli SP, Murmu KC, Jain A, Krishna S, Sahoo BS, Chattopadhyay S, Rusten TE, Prasad P, Chauhan S, Chauhan S. Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response. EMBO Reports. 2020
Raghav S, Ghosh A, Turuk J, Kumar S, Jha A, Madhulika S, Priyadarshini M, Biswas VK, Shyamli PS, Singh B, Singh N, Singh D, Datey A, Avula K, Smita S, Sabat J, Bhattacharya D, Kshatri JS, Vasudevan D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Swain R, Chattopadhyay S, Syed GH, Dixit A, Prasad P; Odisha COVID-19 Study Group; ILS COVID-19 Team, Pati S, Parida A. Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity. Frontiers in Microbiology. 2020

2019

Dey D, Siddiqui SI, Mamidi P, Ghosh S, Kumar CS, Chattopadhyay S, Ghosh S, Banerjee M. The effect of amantadine on an ion channel protein from Chikungunyavirus. PLOS Neglected Tropical Diseases. 2019
Nayak TK, Mamidi P, Sahoo SS, Kumar PS, Mahish C, Chatterjee S, Subudhi BB, Chattopadhyay S, Chattopadhyay S. P38 and JNK Mitogen-Activated Protein Kinases Interact with Chikungunya Virus Non-Structural Protein-2 and Regulate TNF Induction during Viral Infection in Macrophages. Frontiers in Immunology. 2019
Saswat T, Sahoo N, Muduli S, Debata NK, Chattopadhyay S, Chattopadhyay S. Epidemiological trends and molecular dynamics of dengue, chikungunya virus infection, coinfection, and other undifferentiated fever during 2015-2016 in Odisha, India. Journal of Medical Virology. 2019
Patro ARK, Mohanty S, Prusty BK, Singh DK, Gaikwad S, Saswat T, Chattopadhyay S, Das BK, Tripathy R, Ravindran B. Cytokine Signature Associated with Disease Severity in Dengue. Viruses. 2019

2018

Kumar S, Kumar A, Mamidi P, Tiwari A, Kumar S, Mayavannan A, Mudulli S, Singh AK, Subudhi BB, Chattopadhyay S. Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity. Scientific Reports. 2018

2017

Nayak TK, Mamidi P, Kumar A, Singh LP, Sahoo SS, Chattopadhyay S, Chattopadhyay S. Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages. Viruses. 2017

2016

Mishra P, Kumar A, Mamidi P, Kumar S, Basantray I, Saswat T, Das I, Nayak TK, Subhasis Chattopadhyay S, Subudhi BB, Chattopadhyay S. Inhibition of Chikungunya Virus Replication by 1-[(2-Methylbenzimidazol-1-yl) Methyl]-2-Oxo Indolin-3-ylidene] Amino] Thiourea (MBZM-N-IBT). Scientific Reports.2016

2015

Kumar S, Mamidi P, Kumar A, Basantray I, Bramha U, Dixit A, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S, Chattopadhyay S. Development of novel antibodies against non-structural proteins nsP1, nsP3 and nsP4 of Chikungunya virus: Potential use in basic research. Archives of Virology. 2015
Saswat T, Kumar A, Kumar S, Mamidi P, Muduli S, Debata NK, Pal NS, Pratheek BM., Chattopadhyay S, Chattopadhyay S. High rates of co-infection of Dengue and Chikungunya virus in Odisha and Maharashtra, India during 2013. Infection, Genetics and Evolution. 2015
Pratheek BM, Suryawanshi AR, Chattopadhyay S, Chattopadhyay S. In silico analysis of MHC-I restricted epitopes of Chikungunya virus proteins: Implication in understanding anti-CHIKV CD8(+) T cell response and advancement of epitope based immunotherapy for CHIKV infection. Infection, Genetics and Evolution. 2015

2014

Chattopadhyay S, Kumar A, Mamidi P, Nayak TK, Das I, Chhatai J, Basantray I, Bramha U, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S. Development and characterization of monoclonal antibody against non-structural protein-2 of Chikungunya virus and its application. Journal of Virological Methods. 2014
Kumar A, Mamidi P, Das I, Nayak TK, Kumar S, Chhatai J, Chattopadhyay S, Suryawanshi AR, Chattopadhyay S. A novel 2006 Indian outbreak strain of Chikungunya virus exhibits different pattern of infection as compared to prototype strain. PLOS One. 2014
Das I, Basantray I, Mamidi P, Nayak TK, B M P, Chattopadhyay S, Chattopadhyay S. Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection. PLOS One. 2014

2007

Chattopadhyay S, Weller SK. Direct interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer. Journal of Virology. 2007

2006

Chattopadhyay S, Weller SK. DNA binding activity of the herpes simplex virus type 1 origin binding protein, UL9, can be modulated by sequences in the N terminus: correlation between transdominance and DNA binding. Journal of Virology. 2006
Varghese V, Ghosh S, Das S, Bhattacharya SK, Krishnan T, Karmakar P, Kobayashi N, Naik TN. Characterization of VP1, VP2 and VP3 gene segments of a human rotavirus closely related to porcine strains. Virus Genes. 2006

2005

Chaudhuri S, Das S, Chowdhury A, Santra A, Bhattacharya SK, Naik TN. Molecular epidemiology of HCV infection among acute and chronic liver disease patients in Kolkata, India. Journal of Clinical Virology. 2005

2004

Das S, Varghese V, Chaudhuri S, Barman P, Kojima K, Dutta P, Bhattacharya SK, Krishnan T, Kobayashi N, Naik TN. Genetic variability of human rotavirus strains isolated from Eastern and Northern India. Journal of Medical Virology. 2004
Barman P, Ghosh S, Das S, Varghese V, Chaudhuri S, Sarkar S, Krishnan T, Bhattacharya SK, Chakrabarti A, Kobayashi N, Naik TN. Sequencing and sequence analysis of VP7 and NSP5 genes reveal emergence of a new genotype of bovine group B rotaviruses in India. Journal of Clinical Microbiology. 2004
Varghese V, Das S, Singh NB, Kojima K, Bhattacharya SK, Krishnan T, Kobayashi N, Naik TN. Molecular characterization of a human rotavirus reveals porcine characteristics in most of the genes including VP6 and NSP4. Archives of Virology. 2004

2003

Das S, Varghese V, Chaudhury S, Barman P, Mahapatra S, Kojima K, Bhattacharya SK, Krishnan T, Ratho RK, Chhotray GP, Phukan AC, Kobayashi N, Naik TN. Emergence of novel human group A rotavirus G12 strains in India. Journal of Clinical Microbiology. 2003

2002

Das S, Sen A, Uma G, Varghese V, Chaudhuri S, Bhattacharya SK, Krishnan T, Dutta P, Dutta D, Bhattacharya MK, Mitra U, Kobayashi N, Naik TN. Genomic diversity of group A rotavirus strains infecting humans in eastern India. Journal of Clinical Microbiology. 2002

2001

Sen A, Kobayashi N, Das S, Krishnan T, Bhattacharya SK, Naik TN. The evolution of human group B rotaviruses. The Lancet. 2001

2000

Sen A, Kobayashi N, Das S, Krishnan T, Bhattacharya SK, Urasawa S, Naik TN. Amplification of various genes of human group B rotavirus from stool specimens by RT-PCR. Journal of Clinical Virology. 2000

1999

Krishnan T, Sen A, Choudhury JS, Das S, Naik TN, Bhattacharya SK. Emergence of adult diarrhoea rotavirus in Calcutta, India. The Lancet. 1999

Review articles:

Kumar, P. S., Radhakrishnan, A., Mukherjee, T., Khamaru, S., Chattopadhyay, S., & Chattopadhyay, S. (2022). Understanding the role of Ca²⁺ via transient receptor potential (TRP) channel in viral infection: Implications in developing future antiviral strategies. Virus research
Subudhi BB, Chattopadhyay S, Chattopadhyay S. Targeting host factors of virus-induced inflammation: a strategy for tackling future epidemics by RNA viruses. Future Virology. 2022
Translational Research Consortia (TRC) for Chikungunya Virus in India. Current Status of Chikungunya in India. Frontiers in Microbiology. 2021
Subudhi BB, Chattopadhyay S, Mishra P, Kumar A. Current Strategies for Inhibition of Chikungunya Infection. Viruses. 2018
Pratheek BM, Nayak TK, Sahoo SS, Mohanty PK, Chattopadhyay S, Chakraborty NG, Chattopadhyay S. Mammalian non-classical major histocompatibility complex I and its receptors: Important contexts of gene, evolution, and immunity. Indian Journal of Human Genetics. 2014
Pratheek BM, Saha S, Maiti PK, Chattopadhyay S, Chattopadhyay S. Immune regulation and evasion of Mammalian host cell immunity during viral infection. Indian Journal of Virology. 2013
Chattopadhyay S, Chen Y, Weller SK. The two helicases of herpes simplex virus type 1 (HSV-1). Frontiers in Bioscience. 2006

Patents filed/granted:

Granted:

Patent No.: 347450; Priority Date: 12.12.2014; Grant date:19.09.2020. Chattopadhyay S, Kumar A, Subudhi BB, Mishra P. A composition for inhibition of infection caused by Chikungunya virus (CHIKV).

Filed:

Application No.: 202031033920. BB Subudhi, R N Dash, Alok Kumar Moharana, P Mamidi, S Chattopadhyay. Anti-CHIKV Ibuprofen conjugates and method of preparation thereof. Filing date: 07/08/2020.
Application No.: 201931012926. BB Subudhi, R N Dash, T K Mohapatra, P Mamidi, S Chattopadhyay. Antiviral Drug Conjugate Composition. Filing Date: 30/03/2019.