Profile
My laboratory is primarily focus on promoting the documentation, scientific validation and evaluation of traditional healthcare practices. This includes the ethnobotany and ethnopharmacological perspectives of medicinal plants including their cultivation, promotion, value addition and chemical profiling, and promotion of start-ups based on development of herbal medicinal products (AYUSH drugs, Phytopharmaceuticals, nutraceuticals etc). to full fill the mandate of the institute various medicinal plants of the region are targeted for their documentation, extraction, isolation, characterization, value-addition, development of marker compounds, qualitative evaluation and standardization. Priority therapeutic areas which my laboratory is targeting include anti-diabetic, anti-cancer, bronchial asthma, gastro-protectives and immuno-modulation. In addition, Value-addition to the traditional knowledge is also targeted which can lead to the cause of translational and transformational research through Medicinal plants of the NER.
Current Focus Areas
Documentation of traditional healthcare practices and Healers of NER.
Validation of the traditional medicine/practices for lead identification and product development through translational approach including standardization of extraction procedures, total phytochemical studies, biological efficacy studies (both in vitro and in vivo) with an aim to identify the potential research leads (at pre-clinical level)
Chemical profiling and metabolic studies of the bioresources of the North east region.
Selected Publications
1) Kshetrimayum, Vimi, Rameshwari Heisnam, Ojit Singh Keithellakpam, Pullapanthula Radhakrishnanand, Sai Jyothi Akula, Pulok K. Mukherjee, and Nanaocha Sharma. "Paris polyphylla Sm. Induces reactive oxygen species and caspase 3-mediated apoptosis in colorectal cancer cells in vitro and potentiates the therapeutic significance of fluorouracil and cisplatin." Plants 12, no. 7 (2023): 1446.
2) Chanu, Khaidem Devika, Nanaocha Sharma, Vimi Kshetrimayum, Sushil Kumar Chaudhary, and Pallab Kanti Haldar. "Ageratina adenophora (Spreng.) King & H. Rob. Standardized leaf extract as an antidiabetic agent for type 2 diabetes: An in vitro and in vivo evaluation." Frontiers in Pharmacology 14 (2023): 1178904
3) Chanu, Khaidem Devika, Soibam Thoithoisana, Amit Kar, Pulok Kumar Mukherjee, P. Radhakrishnanand, Keyur Parmar, and Nanaocha Sharma. "Phytochemically analysed extract of Ageratina adenophora (Sprengel) RM King & H. Rob. initiates caspase 3-dependant apoptosis in colorectal cancer cell: A synergistic approach with chemotherapeutic drugs." Journal of Ethnopharmacology 322 (2024): 117591
4) Chaudhary, Sushil K., Ojit Singh Keithellakpam, Salem Lalvenhimi, Joydeb Chanda, Shovonlal Bhowmick, Amit Kar, Bunindro Nameirakpam et al. "Chemo diversity of ginger-a potent crop in Manipur and its acetylcholinesterase (AChE) inhibitory potential." Biochemical Systematics and Ecology 106 (2023): 104560
5) Rameshwari Heisnam, Soibam Thoithoisana Devi, Sibasish Mohanty, Pulok K Mukherjee, VVS Prasanna Kumari Rayala, Pullapanthula Radhakrishnanand, Rupesh Dash, Nanaocha Sharma (Feb 2024). Tolypothrix Dichloromethane Ethylacetate fraction (TDEF) inhibits cisplatin resistance H357 cell through PI3K/AKT/beta-catenin pathway. Am J Cancer Res, ISSN:2156-6976/ajcr0152359