Profile
PhD: Institute of Microbial Technology (IMTECH)/Panjab University, Chandigarh, India (1999) Postdoctoral research: Harvard Medical School, Boston, MA, USA (1999-2001) Johns Hopkins School of Medicine, Baltimore, MD, USA (2001-2006)
Current Focus Areas
Invasive mycoses pose a serious therapeutic challenge. Candida (Nakaseomyces) glabrata, a non-dimorphic fungal pathogen, is a common cause of invasive Candida. Our research is focussed on delineating the strategies that C. glabrata employs to acquire resistance to antifungal drugs and survive antimicrobial environment of the mammalian host.
Selected Publications
1. Askari, F., Vasavi, B. and Kaur, R. (2023) Phosphatidylinositol 3-phosphate regulates iron transport via PI3P-binding CgPil1 protein. Cell Reports 42(8): 112855. DOI: 10.1016/j.celrep.2023.112855 2. Bhakt, P., Raney, M. and Kaur, R. (2022) The SET-domain protein CgSet4 negatively regulates antifungal drug resistance via the ergosterol biosynthesis transcriptional regulator CgUpc2a. Journal of Biological Chemistry 298(10):102485. 3. Battu, A., Purushotham, R., Dey, P., Vamshi, S.S. and Kaur, R. (2021) An aspartyl protease-mediated cleavage regulates structure and function of a flavodoxin-like protein and aids oxidative stress survival. PLoS Pathogens 17: e1009355. 4. Kumar, K., Moirangthem, R. and Kaur, R. (2020) Histone H4 dosage modulates DNA damage response in the pathogenic yeast Candida glabrata via homologous recombination pathway. PLoS Genetics 16: e1008620. 5. Rai, M.N., Balusu, S., Gorityala, N., Dandu, L. and Kaur, R. (2012) Functional genomic analysis of Candida glabrata-macrophage interaction: Role of chromatin remodeling in virulence. PLoS Pathogens 8: e1002863.