Profile
Dr. Shweta Tyagi obtained her Ph.D. from the International Centre for Genetic Engineering & Biotechnology, New Delhi. She carried out her post-doctoral research with Prof. Winship Herr at Cold Spring Harbor Laboratory, New York and later at Center for Integrative Genomics, University of Lausanne, Switzerland. Shweta joined the Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad as Group Leader in 2010. Her group focuses on how chromatin modifiers regulate molecular pathways of biomedical importance and, how perturbation of these functions may promote oncogenesis.
Current Focus Areas
# We are investigating the role of MLL family in shaping the epigenetic landscape of centromeres.
# We are interested in understanding how H3K4 methylation regulates transcription of RNA Polymerase I
# We have shown that MLL complex localizes to spindle microtubules, and centrosome and RNAi of the MLL complex severely compromises chromosome alignment during metaphase. We aim to understand the molecular interactions of MLL involved in these pathways.
Selected Publications
Malik et al., (2023) MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres. PLOS Biology21(6):e3002161
Chinchole et al (2022) MLL regulates the actin cytoskeleton and cell migration by stabilising Rho GTPases via the expression of RhoGDI1. J Cell Sci. 135 (20)
Zargar et al.,(2018). Dynamic site- specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters. Nucleic Acids Research. 46(1): 174–188
Ali et al., (2017) MLL/WDR5 complex regulates Kif2A localization to ensure chromosome congression and proper spindle assembly during mitosis. Developmental Cell. 41(6): 605-622