Profile
Working on the exploration and diversity analysis of bacteria and fungi including wild mushroom from different unique ecological niches of NE India for agricultural, therapeutic and nutraceutical applications. She has characterized few antimicrobial microbial peptides against antimicrobial resistant (AMR) and MDR pathogens and their genomic and proteomic analysis & insights into its antimicrobial characteristics have been well studied for the development of antimicrobial drug. Her team also works on antimicrobial bioactive phytocompounds derived from traditionally used medicinal plants against Multidrug Resistant enteric bacteria (MDR) to determine the responses and antimicrobial activities, synergistic effects with conventional antibiotics, mechanism of action based on efflux pump protein, modulation of host immune response, inhibition of biofilm formation etc. Nutraceutical and antimicrobial properties of wild edible mushrooms from Manipur have been studied. Genomics and proteomics analysis has been carried out to identify the gene pathway and identify biosynthetic gene clusters having PGPR & biocontrol activity.
Current Focus Areas
Microbial diversity and bio-prospecting
Study of microbial peptides and plant bioactive metabolites to combat antimicrobial resistant and MDR Pathogens.
Microbes for agricultural applications
Proteome and Genome analysis
Wild edible mushroom for neutraceutical and therapeutic applications.
Selected Publications
Ng Ngashangva, P. Mukherjee, K.C. Sharma, M.C. Kilita and Sarangthem Indira* (2021) “Analysis of Antimicrobial peptide metabolome of bacterial endophyte isolated from traditionally used medicinal plant MillettiapachycarpaBenth” Frontiers in Microbiology. June 2021, volume12. Impact factor – 5.2
Ngashangva N, P. K. Mukherjee, Sharma C, Mohan C.K., Indira S* (2022). Integrated genomics and proteomics analysis of Paenibacilluspeoriae IBSD35 and insights into its antimicrobial characteristics. Scientific reports..https://doi.org/10.1038/s41598-022-23613-y Impact factor- 4.6
S.Agarwal, J.Nandeibam, Indira Sarangthem*(2021) Ultrastructural changes in methicillin-resistant Staphylococcus aureus (MRSA) induced by metabolites of thermophilous fungi Acrophialophoralevis. PLOS ONE DOI https://doi.org/10.1371/Journal.pone.0258607. October 14, 2021. Impact factor-3.75
T A Phazna 1, N G Ngashangva, B. Singh Yentrembam, R. Maurya, P. Mukherjee, C. Sharma, P. K Verma, Indira Sarangthem. (2022) Draft genome sequence and functional analysis of Lysinibacillusxylanilyticus t26, a plant growth promoting bacterium isolated from Capsicum chinense rhizosphere. (JBSC JBSC-D-21-00609R3).J. of Biosc. DOI: 10.1007/s12038-022-00264-9. Impact factor-2.795
S.Huidrom, Ng Ngashangva, J. Khumlianlal, K. C. Sharma1, Pulok K Mukherjee and S.Indira Devi. (2024). Genomic insights of Lactiplantibacillus plantarum BRD3A isolated from Atingba, a traditional fermented rice-based beverage and analysis of its potential for probiotic and antimicrobial activity against Methicillin-resistant Staphylococcus aureus Frontiers in Microbiology. 15:1357818. doi: 10.3389/fmicb.2024.1357818. Impact factor – 5.2