Profile
Overall research focus of our laboratory is to understand and gain insights for; Why some individuals respond with severe, threatening diseases, whereas others display a quiescent progression, or even remain asymptomatic following stimulus challenge. In particular, the lab is keenly interested in unravelling cellular/molecular or genetic mechanisms underlying in healthy and disease aiming for translational approaches. Two major focus areas that the lab is working on LUNG BIOLOGY & CARDIAC BIOLOGY Our distinctive study approaches will lead to address: Disease phenotype, functions, or progression. (Human Cohort). Disease regulation applications (Mice models & Stem cell). Our study findings will demonstrate unexplored heterogenic prototype study of Indian population to decipher the mechanistic events of NLRP-mediated pulmonary or cardiac disease progression. Overall Human iPSC-cardiomyocytes or lung resident mesenchymal stromal cells LR-MSCs derived from the subjects (COPD/CVD), or healthy subjects employed to assess the potential to confirm therapeutics/ interventions from study outcome.
Current Focus Areas
PULMONARY BIOLOGY & CARDIOVASCULAR BIOLOGY
Selected Publications
Deciphering the genetic architecture and ethnographic distribution of IRD in three ethnic populations by whole genome sequence analysis. Biswas P, Borooah S, Raghavendra PB, Ferreyra H, Riazuddin SA, Frazer KA, Ayyagari R. PLoS Genet. 2021 Oct 18;17(10):e1009848.
Detection and validation of novel mutations in MERTK in a simplex case of retinal degeneration using WGS and hiPSC-RPEs model Biswas P, Borooah S, Matsui H, Voronchikhina M, Zhou J, Zawaydeh Q, Raghavendra PB, Ferreyra H, Riazuddin SA, Wahlin K, Frazer KA, Ayyagari R. Hum Mutat. 2021 Feb;42(2):189-199.
A Mouse Model with Ablated Asparaginase and Isoaspartyl Peptidase 1 (Asrgl1) Develops Early Onset Retinal Degeneration (RD) Recapitulating the Human Phenotype.Biswas P, Berry AM, Zawaydeh Q, Bartsch DG, Raghavendra PB, Hejtmancik JF, Khan NW, Riazuddin SA, Ayyagari R.Genes (Basel). 2022 Aug 17;13(8):1461.
The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies. Puvula J, Maddu N, Gutam N, Parimal A, Raghavendra PB. Oncotarget. 2022 Dec 17;13:1323-1340.
Unraveling DPP4 Receptor Interactions with SARS-CoV-2 Variants and MERS-CoV: Insights into Pulmonary Disorders via Immunoinformatics and Molecular Dynamics. Roy AN, Gupta AM, Banerjee D, Chakrabarti J, Raghavendra PB. Viruses. 2023 Oct 6;15(10):2056.