Profile
Dr. Ramanamurthy graduated in Veterinary Science from the College of Veterinary Science, Tirupati. Thereafter he specialized in Veterinary Immunology at the Indian Veterinary Research Institute (IVRI), Bareilly, Uttar Pradesh. He started a career in Lab animal Science as a scientist-B in the year 1992 at the Institute of Microbial Technology (CSIR), Chandigarh. During his tenure there he was instrumental in setting up a genetically sound program for the breeding and supply of inbred strains of mice for research. In the year 1998, moved to DBT- National Centre for Cell Science. He is currently serving as Scientist-G and In charge of the Experimental Animal Facility. At NCCS he is instrumental in initiating the laboratory animal breeding program. He also initiated the ethical oversight program at the Institute in sync with the rules and regulations governing the conduct of experiments on animals. He has been actively involved in collaborative research efforts and co-authored several papers in high-impact journals. He has served on Committees of several National Institutes of repute as an expert member and also serves as a nominated member of CCSEA in several Institutional Animal Ethics Committees.
Current Focus Areas
Overall management of the Experimental Animal facility.Genetic quality control of small lab animals (mice). Research support for the conduct of experiments on animals.
Selected Publications
1. Awasthi A, Mathur R, Khan A, Joshi BN, Jain N, Sawant S, Boppana R, Mitra D, Saha B. CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response. J Exp Med. 2003 Apr 21;197(8):1037-43. Epub 2003 Apr 14. PubMed PMID: 12695487; PubMed Central PMCID: PMC2193877.
Mathur RK, Awasthi A, Wadhone P, Ramanamurthy B, Saha B. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nat Med. 2004 May;10(5):540-4. Epub 2004 Apr 25. Erratum in: Nat Med. 2004 Jul;7(10):755. PubMed PMID: 15107845
Gupta S, Boppana R, Mishra GC, Saha B, Mitra D. HIV-1 Tat suppresses gp120-specific T cell response in IL-10-dependent manner. J Immunol. 2008 Jan 1;180(1):79-88. PubMed PMID: 18097007.
Inamdar S, Joshi A, Malik S, Boppana R, Ghaskadbi S. Vitexin alleviates non-alcoholic fatty liver disease by activating AMPK in high fat diet fed mice. Biochem Biophys Res Commun. 2019 Oct 29;519(1):106-112. doi: 10.1016/j.bbrc.2019.08.139. Epub 2019 Aug 29. PMID: 31472955
D Paul, S Islam, RK Manne, US Dinesh, SK Malonia, B Maity, R Boppana, F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear-catenin functionJournal of Pathology 164 (5), 1433-1439