Profile
Dr Satish Devadas is an Immunologist who studies T cell biology in Humans and Mice to better define Adaptive Immune systems in mammals. He has a PhD degree from the University of Madras, Chennai, TN and carried out his dissertation work in Prof. R Puvankrishnan’s laboratory at the Central Leather Research Institute, Chennai, TN. He then joined Dr Mark Williams’ at the American Red Cross, Rockville, Bethesda, MD to study the role of Reactive Oxygen Species in T cell Receptor Activation and Apoptosis. He later was a Research training specialist with Dr. Yufang Shi at the Molecular Genetics Microbiology and Immunology Department, Robert Wood Johnson School of Medicine, Piscataway, NJ. Since Sep 2007 he has been working on Human Immunology at the T cell Biology lab, ILS, Bhubaneswar.
Current Focus Areas
1: Role of Cytotoxic CD8+ T-cells in Lupus Immune pathology 2: IL-21/23 axis modulate inflammation and osteoclastogenic capacity of RA CD4+ T cells: 3: CD4+ T-cell characterization in Type 2 Diabetes mellitus 4: Role of sex hormones in T-cell mediated RA pathology
Selected Publications
Bhattacharya G, Sengupta S, Jha R, Shaw SK, Jogdand GM, Barik PK, Padhan P, Parida JR and Devadas S (2023) IL-21/23 axis modulates inflammatory cytokines and RANKL expression in RA CD4+ T cells via p-Akt1 signaling. Front. Immunol. 14:1235514. 2023 sept 21; https://doi.org/10.3389/fimmu.2023.1235514 Sengupta S, Shaw SK, Chatterjee S, Bhattacharya G, Barik PK, Chattopadhyay S, Devadas S. Perturbations in spike-specific peripheral T follicular helper cells in SARS-CoV2 breakthrough convalescent individuals immunized by BBV152 vaccine. J Med Virol. 2023 Sep;95(9):e29053. doi: 10.1002/jmv.29053. PMID: 37650214. IL-21, Inflammatory Cytokines and Hyperpolarized CD8+ T Cells Are Central Players in Lupus Immune Pathology Sengupta S, Bhattacharya G, Mohanty S, Shubham K. Shaw, Gajendra M. Jogdand, Rohila Jha, Prakash K. Barik, Jyoti R. Parida,* and Devadas S 1,2,*. Underlying Co-Morbidity Reveals Unique Immune Signatures in Type II Diabetes Patients Infected With SARS-CoV2. Sengupta S, Bhattacharya G, Chatterjee S, Datey A, Shaw SK, Suranjika S, Nath P, Barik PK, Prasad P, Chattopadhyay S, Swain RK, Parida A, Devadas S. Front Immunol. 2022 Apr 27;13:848335. iCa2+ Flux, ROS and IL-10 Determines Cytotoxic, and Suppressor T Cell Functions in Chronic Human Viral Infections. Mohanty S, Barik P, Debata N, Nagarajan P, Devadas S. Front Immunol. 2020; 11: 83.