Profile
In their anatomic niche, mammalian cells receive signals from a variety of stimuli that generate crosstalks between signal-activated intracellular pathways. Combining biochemistry, genetics, and computational modelling tools, we have been investigating the role of these cross-regulatory mechanisms in physiology and disease. We are examining crosstalk between the canonical and non-canonical NF-kB pathways and those beyond NF-kB signalling. We are biochemically characterizing crosstalk mechanisms integrating cellular pathways within a network and exploring if such crosstalks have functional relevance for I) inflammation and inflammation-associated ailments, including cancer, or II) for anti-viral immunity. We argue that our crosstalk studies may inform improved therapeutic regimes, which specifically target signalling crosstalk, in the future.