Profile
Dr. Anil Kumar is presently working as Staff Scientist in the National Institute of Immunology, New Delhi. His research interest focuses on microbiota-derived metabolites such as Trimethylamine N-oxide (TMAO), Indoxyl Sulfate, Trimethylamine etc. which have been implicated in human health and disease, and their early detection in the body fluids is thought to be significant in understanding pathogenesis and treatment of colorectal cancer and other diseases. His group is also studying the link of gut microbes in colorectal cancer causation. As an inventor, he credits more than granted 50 patents for developing product & processes useful indifferent industries. He also has published50 research publications in international journals. He had participated in the development of biosensor which has been transferred to industry. In 2012, one of his patents has been selected for CSIR Technology Award 2012 and other US patent won Merck Millipore India Innovation Award 2012. He is also heading IPR division in the National Institute of Immunology.
Current Focus Areas
Recent intriguing data is hinting at a much broader link between microbiota, bacterial infections, inflammation and carcinogenesis. The mechanism of this relationship between bacteria and human cancer is not well studied and understood, hence our laboratory aim to delineate this complex interaction among microbiota, bacterial infections, inflammation and carcinogenesis.
Selected Publications
• Dalal N, Makharia GK, Dalal M, Mohan A, Singh R, Kumar A* (2023) Gut metabolite indoxyl sulfate has selective deleterious and anticancer effect on colon cancer cells. J. Med. Chem. https://doi.org/10.1021/acs.jmedchem.3c01907 *denotes corresponding author • Jalandra R, Sharma M, Makharia GK, Kumar A* (2023) Inflammatory and deleterious role of gut microbiota-derived trimethylamine on colon cells. Front Immunol. 2022; 13: 1101429. doi: 10.3389/fimmu.2022.1101429. *denotes corresponding author • Upadhyay P, Tyagi A, Agrawal S, Kumar A, Gupta S (2023) Bidirectional effect of Triphala on modulating Gut-brain axis to improve cognition in the Murine Model of Alzheimer’s disease. Mol Nutr Food Res. DOI: 10.1002/mnfr.202300104 • Verma D, Sajwan RK, Lakshmi GBVS, Kumar A* and Solanki P (2022) A Molecularly Imprinted Polymer based on Novel Polyaniline–Zinc Sulfide Nanocomposite for Electrochemical Detection of Trimethylamine N-Oxide. Environ. Sci.Nano, 2022,9, 3992-4006. https://doi.org/10.1039/D2EN00624C. *denotes