Profile
Dr. Acharya obtained his Ph. D. degree in microbiology and cell biology from Indian Institute of Science, Bangalore in 2003. He pursued his post-doctoral training at UTMB, Galveston, Texas (USA) from 20023-2011. Currently, he is a senior scientist in the Infectious Disease Biology division at Institute of Life Sciences, Bhubaneswar. He has been an elected fellow of NASI for his significant contribution in the area of DNA replication in eukaryotes and vaccine development against fungal pathogens.
Current Focus Areas
Understanding eukaryotic DNA replication mechanism and the roles of DNA polymerases in human pathological disorers and fungal pathogenesis
Selected Publications
1. Bose Swagata , Sahu Satya Ranjan, Dutta Abinash , and Acharya Narottam (2024) A chemically-induced attenuated strain of Candida albicans generates robust protective immune response and prevents systemic candidiasis development. eLife, (https://doi.org/10.7554/eLife.93760.1)
2. Sahu Satya Ranjan, Thakur Shweta, Peroumal Doureradjou, Utkalaja Bhabasha Gyanadeep, Dutta Abinash, Kumari Premlata, Subhadarsini Ipsita, and Acharya Narottam (2023) 4-Nitroquinoline 1-oxide induces immune-cells death to onset early immunosuppression during Oral squamous cell carcinoma development. Frontiers in Immunology, 14:1274519. doi: 10.3389/fimmu.2023.1274519.
3. Kumari Premlata, Sahu Satya Ranjan, Dutta, Utkalaja Bhabasha Gyanadeep, and Acharya Narottam (2023) RAD51-WSS1 dependent genetic pathways are essential for DNA-Protein crosslink repair and pathogenesis in Candida albicans. Journal of Biological Chemistry, doi.org/10.1016/j.jbc.2023.104728. (On the cover page)
4. Patel Shraddheya Kumar , Sahu Satya Ranjan, Utkalaja Bhabasha Gyanadeep, Bose Swagata, and Acharya Narottam (2023) Pol32, an accessory subunit of DNA polymerase delta, plays an essential role in genome stability and pathogenesis of Candida albicans. Gut microbes, DOI: 10.1080/19490976.2022.2163840.
5. Kodavati Manohar, Khandagale Prashant, Patel Shraddheya Kumar, Sahu Jugal Kishor, and Acharya Narottam (2021) Ubiquitin-binding domain of DNA polymerase eta lacking the PCNA-interacting-protein motif directly binds to PCNA and regulates translesion DNA synthesis. Journal of Biological Chemistry, Dec 18;298(2):101506. doi: 10.1016/j.jbc.2021.101506.