Profile

M. Sc. University of Agricultural Sciences, Dharwad, Karnataka, India Ph. D. Temasek Life Sciences Laboratory, Singapore (PhD awarded by Nanyang Technological University, Singapore) Past Affiliations Post Doctoral training Sanford Burnham Prebys Medical Discovery Institute (SBPMDI), La Jolla, USA. University of California San Diego (UCSD), USA La Jolla Institute for Immunology (LJI), La Jolla, USA

Current Focus Areas

  • T cell memory development to infections

  • Neonatal sepsis

  • Immunogenomics

Selected Publications

  • Kar R, Chattopadhyay S, Sharma A, Sharma K, Sinha S, Arimbasseri GA*, and Patil VS*, 2024. Single-cell transcriptomic and T cell antigen receptor analysis of human cytomegalovirus (hCMV)-specific memory T cells reveals effectors and pre-effectors of CD8+- and CD4+-cytotoxic T cells. Immunology. DOI: https://doi.org/10.1111/imm.13783. *corresponding author.

  • Rana K, Pani T, Jha SK, Mehta D, Yadav P, Jain D, Pradhan MK, Mishra S, Kar R, Reshma GB, Srivastava A, Dasgupta U, Patil VS*, and Bajaj A*, 2022, Hydrogel-mediated Topical Delivery of Steroids Can Effectively Alleviate Psoriasis via Attenuating the Autoimmune Responses. Nanoscale https://doi.org/10.1039/D1NR06001E. *co-corresponding author

  • Kar A, Jain D, Kumar S, Rajput K, Pal S, Rana K, Kar R, Jha Sk, Medatwal N, Yavvari PS, Pandey N, Mehta D, Sharma S, Bhattacharya D, Pradhan MK, Sharma RD, Srivastava A, Agrawal U, Mukhopadhyay A, Sengupta S, Patil VS, Bajaj A, Dasgupta U, 2023, A localized hydrogel-mediated chemotherapy causes immunogenic cell death via activation of ceramide-mediated unfolded protein response. Science Advances 9 (26), eadf2746 . DOI: 10.1126/sciadv.adf2746

  • Kumar S, Pal S, Thakur J, Rani P, Rana K, Kar A, Kar R, Mehta D, Jha SM, Pradhan MS, Jain D, Rajput K, Mishra S, Ganguli M, Srivastava A, Dasgupta U, Patil VS, Bajaj A. 2021. Nonimmunogenic Hydrogel-Mediated Delivery of Antibiotics Outperforms Clinically Used Formulations in Mitigating Wound Infections ACS Applied Materials & Interfaces.

  • Patil VS, Madrigal A, Schmiedel BJ, Clarke J, O'Rourke P, deSilva AD, Harris E, Peters B, Seumois G, Weiskopf D, Sette A and Vijayanand P, 2018. Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis. Science Immunology 3, eaan8664 (2018). (featured article rotate).

Skills & Proficiency

Immunogenomics T cell biology infectious diseases single-cell transcriptomics ATAC-seq TCR repertoire human immunology neonatal sepsis viral infections antogen-specific memory T cells