Profile
Metabolic heterogeneity: Primary research is focused on studying cellular metabolism and metabolic heterogeneity implicated in cancer and diabetes. Metabolism is the overall process through which living systems acquire and utilize free energy for their survival. In the recent past, cellular metabolism has emerged as an integral process implicated in generating key signaling molecules associated with various cellular responses and processes including immune response, cell growth, apoptosis, and redox homeostasis. We use mass-spectrometry based proteomics and metabolomics tools and other relevant biochemical methods to understand metabolic heterogeneity.
Current Focus Areas
Cancer cells tend to have heterogeneous metabolic preferences and dependencies which influences therapeutic vulnerabilities and clinical outcomes. Metabolic heterogeneity exists between tumors and even within distinct regions of solid tumors. Our lab is interested in understanding the principles of metabolic regulation and metabolic reprograming, that aid in therapeutics.
Selected Publications
1. KORWAR AM, Hossain A, Lee TJ, Shay AE, Basrur V, Conlon K, Smith PB, Carlson BA, Salis HM, Patterson AD, Prabhu KS. (2021) Selenium-dependent metabolic reprogramming during inflammation and resolution. J. Biol. Chem. Feb 10;296:100410. PMID: 33581115. https://pubmed.ncbi.nlm.nih.gov/33581115/ 2. KORWAR AM, Zhang Q. (2021) Comprehensive Quantification of Carboxymethyllysine-Modified Peptides in Human Plasma. J. Am. Soc. Mass Spectrom. Mar 3;32(3):744-752. PMID: 33512994. https://pubmed.ncbi.nlm.nih.gov/33512994/ 3. KORWAR AM, Vannuruswamy G, Jagadeeshaprasad MG, Jayaramaiah RH, Bhat S, Regin BS, Ramaswamy S, Giri AP, Mohan V, Balasubramanyam M, Kulkarni MJ. (2015) Development of Diagnostic Fragment Ion Library for Glycated Peptides of Human Serum Albumin: Targeted Quantification in Prediabetic, Diabetic, and Microalbuminuria Plasma by Parallel Reaction Monitoring, SWATH, and MSE. Mol. Cell. Proteomics. Aug;14(8):2150-9. PMID: 26023067. https://pubmed.ncbi.nlm.nih.gov/26023067/ 4. KORWAR AM, Bhonsle HS, Chougale AD, Kote SS, Gawai KR, Ghole VS, Koppikar CB, Kulkarni MJ. (2012) Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma. Biochem. Biophys. Res. Commun. Mar 16;419(3):490-4. PMID: 22366088. https://pubmed.ncbi.nlm.nih.gov/22366088/ 5. Bhonsle HS, KORWAR AM, Kote SS, Golegaonkar SB, Chougale AD, Shaik ML, Dhande NL, Giri AP, Shelgikar KM, Boppana R, Kulkarni MJ. (2012) Low plasma albumin levels are associated with increased plasma protein glycation and HbA1c in diabetes. J. Proteome Res. Feb 3;11(2):1391-6. PMID: 22181049. https://pubmed.ncbi.nlm.nih.gov/22181049/