Profile
Understanding the mechanisms of genome integrity in nucleus and mitochondria using biochemical and cell biology tools and all contemporary techniques and animal models
Current Focus Areas
Understanding the mechanisms of genome integrity in nucleus and mitochondria using biochemical and cell biology tools and all contemporary techniques and animal models
Selected Publications
1. Kaur E, Agrawal R, Arun R, Madhavan V, Srivastava V, Kumar D, Rath PP, Kumar N, Vedagopuram S, Pandey N, Priya S, Legembre P, Gourinath S, Bajaj A, Sengupta S (2024). Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models. J Clin Invest. e161941. PMID: 38421735 2. Hussain M, Mohammed A, Saifi S, Khan A, Kaur E, Priya S, Agarwal H, Sengupta S (2021). MITOL-dependent ubiquitylation negatively regulates the entry of PolA into mitochondria. PLoS Biol. 19(3): e3001139. PMID: 33657094 3. Priyadarshini R, Hussain M, Attri P, Kaur E, Tripathi V, Priya S, Dhapola P, Saha D, Madhavan V, Chowdhury S, Sengupta S (2018). BLM potentiates c-Jun degradation and alters its function as an oncogenic transcription factor. Cell Rep. 24(4):947-961. PMID: 30044990. 4. Tripathi V, Agarwal H, Priya S, Batra H, Modi P, Pandey M, Saha D, Raghavan SC, Sengupta S (2018). MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways. Nat Commun. 9(1):1016. PMID: 29523790. 5. Tikoo S, Madhavan V, Hussain M, Miller ES, Arora P, Zlatanou A, Modi P, Townsend K, Stewart GS, Sengupta S (2013) Ubiquitin-dependent recruitment of the Bloom Syndrome helicase in response to replication stress is required to suppress homologous recombination. EMBO J. 32(12): 1778-1792. PMID: 23708797