Dr Kuldeep Verma

Staff Scientist-IV, BRIC-CDFD

Profile

Dr. Kuldeep Verma earned his PhD in Biotechnology (2012) from the Indian Institute of Soybean Research, Indore (with Kurukshetra University). After a brief stint at Bejo Seed Ltd. (joint venture Bejo Zaden B. V. Netherlands) Jalna, as a Scientist, he was awarded Postdoctoral Research Associateship from the Department of Biotechnology in 2013. He completed his postdoctoral training at the Indian Institute of Science Education and Research (IISER), Bhopal, where he developed interest in membrane transport machinery in pathogenic amoeba. He continued his research in membrane trafficking and host-virus interaction as a Young Investigator awardee (2017) at the Regional Centre for Biotechnology (RCB-UNESCO), Faridabad. Kuldeep joined the Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad in 2021. His current research focuses on understanding the molecular mechanisms for tissue destruction mediated by single-celled human pathogens Entamoeba histolytica and Naegleria fowleri.

Current Focus Areas

  • Understanding the mechanism of trogocytosis in amoebas

  • Investigating the mechanism of cyclic activity of non-canonical Rab proteins

Selected Publications

  • Batra S, Pancholi P, Roy M, Kaushik S, Jyoti A, Verma K, Srivastava VK. (2021) Exploring insights of syntaxin superfamily proteins from Entamoeba histolytica: a prospective simulation, protein-protein interaction, and docking study. J Mol Recognit. doi: 10.1002/jmr.2886.

  • Kumar H. Pushpa, Kumari A. Verma K. Pergu R. Myalavarrapu S. (2019) The exocyst complex and Rab5 are required for abscission by localizing ESCRT III subunits to the cytokinetic bridge. Journal of Cell Science DOI: 10.1242/jcs.226001.

  • Verma K. Datta S. (2017) The monomeric GTPase Rab35 regulates phagocytic cup formation and phagosomal maturation in Entamoeba histolytica. Journal of Biological Chemistry DOI: 10.1074/jbc.M117.775007

  • Verma K. Y Nozaki Y Datta S. (2016) Role of EhRab7A in phagocytosis of type 1 fimbriated E. coli by Entamoeba histolytica. Molecular Microbiology 102(6):1043-1061. DOI: 10.1111/mmi.13533

  • Verma K. Saito Nakano Y Nozaki Y Datta S. (2015) Insights into endosomal maturation of human holo-transferrin in the enteric parasite Entamoeba histolytica: essential roles of Rab7A and Rab5 in biogenesis of giant early endocytic vacuoles. Cellular Microbiology 17(12):1779-96. DOI: 10.1111/cmi.12470

Skills & Proficiency

Entamoeba histolytica Membrane Trafficking Phagocytosis Trogocytosis Macropinocytosis Rab GTPases V-ATPase complex Cell Cortex Naegleria fowleri. Microscopy
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