Profile
Dr. Agam P. Singh is currently working as Staff Scientist at National Institute of Immunology, New Delhi, India. Prior to joining NII, Agam had worked as associate scientist in the division of Immunology department of Pathology, at NYU medical centre, New York, USA. There he worked on role of Plasmodium circumsporozoite protein in malaria liverstage development. The other area he worked concerned with preclinical vaccine development. The research projects at ICGEB new delhi were aimed at determining Receptor-ligand interactions involved in erythrocyte invasion by Plasmodium knowlesi. His work was focused on understanding the interaction of Plasmodium knowlesi alpha protein with its receptor at functional and structural level. The inhibition studies with Pk-alpha-RII antibodies provided support for inclusion of DBL domains as vaccine candidate. He had worked with eminent scientists like Prof. Victor Nussenzweig at NYU, Ralph M. Steinman, Charles M. Rice at Rockefeller, both Universities in New York, USA.
Current Focus Areas
Malaria 2nd generation Vccaine development with > 75% efficacy.
Host pathogen interactions
Selected Publications
A Sporozoite and Liverstage Expressed Tryptophan Rich Protein Plays an Auxiliary Role in Plasmodium Liver Stage Development and is a Potential Vaccine Candidate Dabbu Kumar Jaijyan, Himanshu Singh, and Agam Prasad Singh* J. Biol. Chem. 290 (32):19496–19511
Identification and characterization of protective CD8+ T epitopes in a malaria vaccine candidate SLTRiP Afshana Quadiri, Inderjeet Kalia, Mohammad Kashif, Agam Prasad Singh # Immunity, Inflammation and Disease [Wiley Publishers] PMID:31967737 doi: 10.1002/iid3.283
Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite AP Singh*, CA Buscaglia, Q Wang, A Levay, DR Nussenzweig, JR Walker, Cell 131 (3), 492-504
Novel antiplasmodial compounds leveraged with multistage potency against Parasite Plasmodium falciparum: In vitro, in vivo evaluations and pharmacokinetic studies Sharma, Neha; Kashif, Mohammad ; Singh, Vigyasa; Fontinha, Diana; Mukherjee, Budhaditya; Kumar, Dhruv ; Singh, Shailja; Prudêncio, Miguel; Singh, Agam *; Rathi, Brijesh* Journal of Medicinal Chemistry https://doi.org/10.1021/acs.jmedchem.1c00659
Plasmodium berghei-Released Factor, PbTIP, Modulates the Host Innate Immune Responses Inderjeet Kalia, Rajesh Anand, Afshana Quadiri, Shreya Bhattacharya, Bijayalaxmi Sahoo, Agam Prasad Singh* Published: 07 December 2021 DOI: 10.3389/fimmu.2021.699887 Frontiers in Immunology