Profile
Dr. Sreedhar Chinnaswamy is a veterinary clinician trained in molecular biology and genetics. He has interests in molecular immunology and seeks to use new-age tools including OMICS methodologies to understand animal diseases with an aim to design suitable interventions. He has worked as an independent researcher on the genetics of infectious diseases in humans at the BRIC-National Institute of Biomedical Genomics, Kalyani from the year 2010, before joining NIAB in 2024. He is a recipient of the Wellcome Trust DBT India Alliance Intermediate fellowship in the past, and has served on various GoI funding agencies as an expert member in the area of infectious diseases. He obtained his PhD from the Dept. of Biochemistry and Biophysics, Texas A&M University at College Station TX, USA in the year 2010. Before that he obtained two master's degrees, one in Chemistry from the New Mexico State University, NM, USA and the other in Animal Biochemistry from the Indian Veterinary Research Institute, UP, India in 2005 and 2003 respectively. He obtained his bachelor's degree in Veterinary Sciences and Animal Husbandry (BVSc & AH) in the year 1999 from the Bangalore Veterinary College, formerly under the University of Agricultural Sciences, GKVK, Bangalore, Karnataka, India.
Current Focus Areas
My lab at NIAB focuses on molecular immunology in animal health and disease
Selected Publications
Evidence for a sex-dependent effect modification in the association between IFN-λ DNA polymorphisms and expression of IFN-λ and interferon-stimulated genes in human PBMCs. Roy D-G, De M Bharatiya S, Khedekar DA, Datta K, Bhattacharjee S, Chinnaswamy, S. Cytokine, 2024, Vol. 184, 156779,
IFN-λ3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model while it shows significant association with leishmaniasis in humans. De M, Sukla S, Bharatiya S, Keshri S, Roy DG, Roy S, Dutta D, Saha S, Ejazi SA, Ravichandiran V, Ali N, Chatterjee M, Chinnaswamy S. Infect Immun. 2024 Jan 9:e0050423. doi: 10.1128/iai.00504-23. Epub ahead of print. PMID: 38193711.
Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages. De M, Bhushan A, Grubbe WS, Roy S, Mendoza JL, Chinnaswamy S. 2022. Genes Immun. 23: 73–84 PMID: 35115664 PMID: 35115664.
Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-λ3 or IFN-λ4 show distinct phenotypes. De M, Bhushan A, Chinnaswamy S. J Leukoc Biol. 2021, 110(2): 357-374. PMID: 33205487
Gene-disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections. Chinnaswamy S. Genes Immun. 2016 Jul;17(5):265-75. doi: 10.1038/gene.2016.24. Epub 2016 Jun 9. PMID: 27278127