Profile
Associate Professor, BRIC-NIBMG, 2019-present Assistant Professor, NIBMG, 2010-2019 Intermediate Fellow; DBT-Wellcome India Alliance; 2017 Visiting Scientist; Healthy Ageing Research Centre, Dept. of Immunology, Rheumatology and Allergy, Medical University of Lodz, Poland; 2015 Visiting Fellow; Jawaharlal Nehru Canter for Advanced Scientific Research, 2012 Dean’s List; New Mexico State University, Las Cruces, NM, USA; 2005 Teaching and Research Assistant, Dept. of Chemistry & Biochemistry, NMSU and Dept. of Biochemistry & Biophysics, TAMU, 2003-2010 Junior Research Fellowship; ICAR for pursuing MVSc degree; 2000 Education: 2010 Ph.D Texas A&M University at College Station, TX, USA 2005 MS New Mexico State University at Las Cruces, NM, USA 2003 MVSc Indian Veterinary Research Institute, UP, India 1999 BVSc&AH Veterinary College, Bangalore, Karnataka, India
Current Focus Areas
My interests revolve around the genetics and biology of type III interferons (IFN). I am interested in their roles in various infectious and inflammatory diseases.
Selected Publications
De M, Sukla S, Bharatiya S, Keshri S, Roy DG, Roy S, Dutta D, Saha S, Ejazi SA, Ravichandiran V, Ali N, Chatterjee M, Chinnaswamy S. IFN-λ3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model while it shows significant association with leishmaniasis in humans. Infect Immun. 2024 Jan 9:e0050423. doi: 10.1128/iai.00504-23. Epub ahead of print. PMID: 38193711. Bharatiya S, Agarwal A, Chinnaswamy S. A Novel Inactive Isoform with a Restored Reading Frame Is Expressed from the Human Interferon Lambda 4 TT Allele at rs368234815. J Interferon Cytokine Res. 2023 Mar 7. doi: 10.1089/jir.2022.0199. Epub ahead of print. PMID: 36880961. Roy DG, Singh L, Chaturvedi HK, Chinnaswamy S. Gender-dependent multiple cross-phenotype association of interferon lambda genetic variants with peripheral blood profiles in healthy individuals. Mol Genet Genomic Med. 2024;12:e2292. PMID: 37795763. De M, Bhushan A, Grubbe WS, Roy S, Mendoza JL, Chinnaswamy S. Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages. Genes Immun. 2022 Feb 3. doi: 10.1038/s41435-022-00164-w. Epub ahead of print. PMID: 35115664. Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-λ3 or IFN-λ4 show distinct phenotypes. De M, Bhushan A, Chinnaswamy S. J Leukoc Biol. 2020 Nov 17. doi: 10.1002/JLB.3A0120-001RRR. Online ahead of print. PMID: 33205487
Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages. De M, Bhushan A, Grubbe WS, Roy S, Mendoza JL, Chinnaswamy S. 2022. Genes Immun. 23: 73–84 PMID: 35115664 PMID: 35115664.
Functional genetic variants of the IFN-λ3 (IL28B) gene and transcription factor interactions on its promoter. Roy S, Roy DG, Bhushan A, Bharatiya S, Chinnaswamy S. Cytokine, 2021, 142, 155491.PMID: 33725487
Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-λ3 or IFN-λ4 show distinct phenotypes. De M, Bhushan A, Chinnaswamy S. J Leukoc Biol. 2021, 110(2): 357-374. PMID: 33205487
Confounding by Single Nucleotide Polymorphism rs117648444 (P70S) Affects the Association of Interferon Lambda Locus Variants with Response to Interferon-α-Ribavirin Therapy in Patients with Chronic Genotype 3 Hepatitis C Virus Infection. Bhushan A, Ghosh S, Bhattacharjee S, Chinnaswamy S. J Interferon Cytokine Res. 2017 Aug;37(8):369-382. doi: 10.1089/jir.2017.0002. Epub 2017 Jul 20. PMID: 28727946