Profile
The major focus of our laboratory is to explore how mammalian long noncoding RNAs [lncRNAs] regulate gene expression and to develop a mechanistic understanding of how these lncRNAs regulate events associated with oncogenesis. Our research group is involved in comprehensive characterization of novel lncRNA-protein network orchestrating the mammalian cell cycle program. Further, our interest also extends towards investigating the role of lncRNAs in DNA replication stress response, DNA damage and repair, genome stability; and in oncogenic or tumor suppressive functions of lncRNAs in cancer. Additionally, our laboratory also focusses on how various RNA modifications modulate the activity of ncRNAs.
Current Focus Areas
lncRNA-protein interactions during DNA replication, DDR and maintenance of genomic integrity
Oncogenic and/or tumor suppressive functions of lncRNAs in cancer
lncRNA modifications and their functional implications in various biological processes
lncRNA-mediated regulation of LLPS of nuclear proteins
Selected Publications
Antagonism between splicing and microprocessor complex dictates the serum-induced processing of lnc-MIRHG for efficient cell cycle reentry. Sun Q, Hao Q, Lin YC, Song YJ, Bangru S, Arif W, Tripathi V, Zhang Y, Cho JH, Freier SM, Jenkins LM, Ma J, Yoon JH, Kalsotra A, Lal A, Prasanth SG, Prasanth KV. RNA. Nov;26(11):1603-1620. doi: 10.1261/rna.075309.120. Epub 2020 Jul 16.PMID: 32675111
The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway. Hao Q, Zong X, Sun Q, Lin YC, Song YJ, Hashemikhabir S, Hsu RY, Kamran M, Chaudhary R, Tripathi V, Singh DK, Chakraborty A, Li XL, Kim YJ, Orjalo AV, Polycarpou-Schwarz M, Moriarity BS, Jenkins LM, Johansson HE, Zhu YJ, Diederichs S, Bagchi A, Kim TH, Janga SC, Lal A, Prasanth SG, Prasanth KV. Elife. 2020 Oct 27;9:e55102. doi:10.7554/eLife.55102.PMID: 33108271.
Functional annotation of human long noncoding RNAs via molecular phenotyping. Ramilowski JA, Yip CW, Agrawal S, Chang JC, Ciani Y, Kulakovskiy IV, Mendez M, Ooi JLC, Ouyang JF, Tripathi V, Ulitsky I, Verardo R, Vorontsov IE, Yamamoto C, Young RS, Baillie JK, Forrest ARR, Guigó R, Hoffman MM, Hon CC, Kasukawa T, Kauppinen S, Kere J, Lenhard B, Schneider C, Suzuki H, Yagi K, de Hoon MJL, Shin JW, Carninci P. Genome Res. 2020 Jul;30(7):1060-1072. doi: 10.1101/gr.254219.119. Epub 2020 Jul 27.PMID: 32718982.
Technological Developments in lncRNA Biology. Jathar S, Kumar V, Srivastava J, Tripathi V (2017). Adv Exp Med Biol.1008:283-323. doi: 10.1007/978-981-10-5203-3_10. Review.
Sun Q*, Tripathi V*#, Yoon JH#, Singh DK, Hao Q, Min KW, Davila S, Zealy RW, Li XL, Polycarpou-Schwarz M, Lehrmann E, Zhang Y, Becker KG, Freier SM, Zhu Y, Diederichs S, Prasanth SG, Lal A, Gorospe M, Prasanth KV# (2018). MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs. Nucleic Acids Res. Nov 2;46(19):10405-10416. doi: 10.1093/nar/gky696. # co-corresponding author, *co-first author.