Profile
Dr. Manas Kumar Santra is a Senior Scientist working at National Center for Cell Science (NCCS), Pune, Maharashtra, India. He has received Ph. D. in Biotechnology from Indian Institute of Technology, Mumbai, India. He did his postdoctoral research at University of Massachusetts Medical School. He has joined National Centre for Cell Science in the year 2010. Dr. Santra’s Laboratory is interested to understand the importance of ubiquitin ligases/kinases/protein phosphatases in cellular processes including cell cycle progression, cell death, cellular signaling, and genome instability associated with cancer pathogenesis and develops lead anticancer agents. Dr. Santra has received several International and National awards such as Charles A. King Trust Research Fellowship Award, National Bioscience Award for Career Development, Ramalingaswami Fellowship, Innovative Young Biotechnologist Award, IUBMB-Sigma Aldrich Corporation Travel Scholarship, ISCA Young Scientist Award, Best research scholar award from IIT Bombay. He is a Fellow of National Academy of Science (FNASc), Allahabad.
Current Focus Areas
My laboratory is interested to identify the critical players associated with immune evasion, deregulated epigenetics, cellular signaling, cell cycle progression, cell death resistance, DNA damage response and repair, genomic instability, during cancer pathogenesis and elucidate the molecular mechanism. Dr. Santra’s laboratory is also interested to develop target based anticancer agents.
Selected Publications
Choppara, Srinadh, Malonia, Sunil K., Sankaran, Ganga, Green Michael R. and Santra Manas K. (2018) Degradation of FBXO31 by APC/C is regulated by AKT- and ATM-mediated phosphorylation. Proc. Natl. Acad. Sci. USA., 115, 998 – 1003. Barik Ganesh K., Sahay, Osheen, Mukhopadhyay, A., Manne, Rajesh K., Islam, Sehban, Roy, A., Nath, Somsubhra. and Santra, Manas K. (2023) FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis. Cell Death Dis. 14, 623. Islam Sehban, Dutta Parul, Sahay Osheen, Gopalakrishnan K, Roy Muhury S, Parameshwar P, Shetty Praveen, Santra, Manas K. (2022) Feedback-regulated transcriptional repression of FBXO31 by c-Myc triggers ovarian cancer tumorigenesis. Int. J. Cancer, 150, 1512 – 1524. Manne Rajesh, K, Agrawal Yashika, Malonia Ssunil K, Banday S, Edachery S, Patel Asha, Kumar A, Shetty Praveen, Santra, Manas K. (2021) FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX. J Biol Chem. 297, 101253. Paul Debasis., Islam, Sehban, Manne, Rajesh K., Dinesh, Umesh S., Malonia, Sunil. K., Maity, B., Boppana, R., Raople, Srikanth, Shetty, Praveen. and Santra, Manas K. (2019) F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function. J. of Pathology, 284, 266–279.