Profile
With broad background in cancer biology, Dr. Sandeep Singh has specific training and expertise in stem-cell biology of cancer, tumor microenvironment and cellular signaling. His research interest includes mechanistic understanding of nongenetic/ epigenetic heterogeneity associated with aggressive tumor behaviour. Dr. Singh's group has developed expertise to define the mechanism of heterogeneity among stem-like cancer cells and its functional interaction in tumor microenvironment. In collaboration with clinicians and other researchers Dr. Singh is contributing to the fundamental understanding of cancer stemness, cellular plasticity and anticancer therapeutics against oral cancer with multidisciplinary approaches.
Current Focus Areas
Aggressive cancer behaviour, drug tolerance and overall poor prognosis has been correlated with intratumoral-heterogeneity; however responsible cellular and molecular determinants have garnered attention, recently. Dr. Singh is focused to comprehend the intrinsic or tumor microenvironment driven cellular plasticity as mechanisms behind intratumoral heterogeneity in oral cancer.
Selected Publications
Kumari P, Ghosh S, Acharya S, Mitra P, Roy S, Ghosh S, Maji M, Singh S, Mukherjee A. (2023). Cytotoxic Imidazolyl-Mesalazine Ester-Based Ru(II) Complexes Reduce Expression of Stemness Genes and Induce Differentiation of Oral Squamous Cell Carcinoma. J Med Chem. Oct 26;66(20):14061-14079. doi: 10.1021/acs.jmedchem.3c01092.
Ghosh S, Mitra P, Saha U, Nandi R, Jena S, Ghosh A, Roy SS, Acharya M, Biswas NK, Singh S.(2023). NOTCH pathway inactivation reprograms stem-like oral cancer cells to JAK-STAT dependent state and provides the opportunity of synthetic lethality. Transl Oncol. Jun;32:101669. doi: 10.1016/j.tranon.2023.101669.
Vipparthi K, Hari K, Chakraborty P, Ghosh S, Patel AK, Ghosh A, Biswas NK, Sharan R, Arun P, Jolly MK, Singh S. (2022). Emergence of hybrid states of stem-like cancer cells correlates with poor prognosis in oral cancer. iScience. May 20;25(5):104317. doi: 10.1016/j.isci.2022.104317
Vipparthi K, Patel AK, Ghosh S, Das S, Das C, Das K, Sarkar A, Thatikonda V, Pal B, Remani ASKN, Arora N, Parihar M, Vijayakumar MV, Bhat MK, Boppana R, Bhattacharjee S, Biswas NK, Arun P, Sharan R, Singh S. (2021). Two novel cell culture models of buccal mucosal oral cancer from patients with no risk-habits of tobacco smoking or chewing. Oral Oncol. Feb;113:105131. doi: 10.1016/j.oraloncology.2020.105131.
Patel AK, Vipparthi K, Thatikonda V, Arun I, Bhattacharjee S, Sharan R, Arun P, Singh S. (2018). A subtype of cancer-associated fibroblasts with lower expression of alpha-smooth muscle actin suppresses stemness through BMP4 in oral carcinoma. Oncogenesis. 2018 Oct 5;7(10):78. doi: 10.1038/s41389-018-0087-x