Bhabatosh Das

Professor, BRIC-THSTI

Profile

Prof. Das is a microbiologist trained at (i) Indian Institute of Technology-Kharagpur (M.Tech. 2003), (ii) CSIR-Indian Institute of Chemical Biology-Kolkata (Ph.D. 2008), (iii) CNRS-Institute of Integrative Biology of the Cell, France (Postdoc. 2011), and (iv) Osaka University (JSPS Fellow, 2017), Japan. His major research focus is to understand the functional repertoires of the human microbiome and develop live biotherapeutics against NAFLD, IBD, sepsis, and PTB. He has published more than 123 peer-reviewed publications in prestigious journals, including The BMJ, PNAS USA, Nature Communications, and Genome Medicine, J, Med. Virol. 

Current Focus Areas

  • Understand the genomic and metagenomic repertoires of the human microbiome for biotherapeutic discovery and development.

Selected Publications

  • Mehrotra T., Konar D., Pragasam AK., Kumar S., Jana P., Babele P., Paul D., Purohit A., Tanwar S., Bakshi S., Das S., Verma J., Talukdar D., Narendrakumar L., Kothidar A., Karmakar SP., Chaudhuri S., Pal S., Jain K., Srikanth CV., Sankar JS., Atmakuri K., Agarwal R., Gaind R., Ballal M., Kammili N., Bhadra RK, Ramamurthy T., Nair GB., Das B. (2023) Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, Genotypic and Proteomic analysis. Proc. Natl. Acad. Sci. U S A 120(33):e2305465120. doi: 10.1073/pnas.2305465120.

  • Purohit A, Kandiyal B, Kumar S, Pragasam AK, Kamboj P, Talukdar D, Verma J, Sharma V, Sarkar S, Mahajan D, Yadav R, Ahmed R, Nanda R, Dikshit M, Banerjee SK, Shalimar, Das B. Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD. iScience. 2023 Dec 26;27(2):108764. doi: 10.1016/j.isci.2023.108764. PMID: 38313048; PMCID: PMC10837629.

  • Pinna NK, Anjana RM, Saxena S, Dutta A, Gnanaprakash V, Rameshkumar G, Aswath S, Raghavan S, Rani CSS, Radha V, Balasubramanyam M, Pant A, Nielsen T, Jørgensen T, Færch K, Kashani A, Silva MCA, Vestergaard H, Hansen TH, Hansen T, Arumugam M, Nair GB, Das B., Pedersen O, Mohan V, Mande SS. Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark. Genome Med. 2021 Mar 3;13(1):36. doi: 10.1186/s13073-021-00851-9. PMID: 33658065; PMCID: PMC7931552.

  • Pant A, Bag S, Saha B, Verma J, Kumar P, Banerjee S, Kumar B, Kumar Y, Desigamani A, Maiti S, Maiti TK, Banerjee SK, Bhadra RK, Koley H, Dutta S, Nair GB, Ramamurthy T, Das B. Molecular insights into the genome dynamics and interactions between core and acquired genomes of Vibrio cholerae. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23762-23773. doi: 10.1073/pnas.2006283117. Epub 2020 Sep 1. PMID: 32873641; PMCID: PMC7519391.

  • Verma J, Bag S, Saha B, Kumar P, Ghosh TS, Dayal M, Senapati T, Mehra S, Dey P, Desigamani A, Kumar D, Rana P, Kumar B, Maiti TK, Sharma NC, Bhadra RK, Mutreja A, Nair GB, Ramamurthy T, Das B. Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6226-6231. doi: 10.1073/pnas.1900141116. Epub 2019 Mar 13. PMID: 30867296; PMCID: PMC6442563.

  • Das B. Insights into TLCΦ lysogeny: A twist in the mechanism of IMEX integration. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18159-18161. doi: 10.1073/pnas.1912633116. Epub 2019 Aug 22. PMID: 31439815; PMCID: PMC6744843.

  • Das B, Chaudhuri S, Srivastava R, Nair GB, Ramamurthy T. Fostering research into antimicrobial resistance in India. BMJ. 2017 Sep 6;358:j3535. doi: 10.1136/bmj.j3535. PMID: 28877874; PMCID: PMC5582344.

  • Pant A, Anbumani D, Bag S, Mehta O, Kumar P, Saxena S, Nair GB, Das B. Effect of LexA on Chromosomal Integration of CTXÏ• in Vibrio cholerae. J Bacteriol. 2015 Oct 26;198(2):268-75. doi: 10.1128/JB.00674-15. PMID: 26503849; PMCID: PMC4751795.

  • Das B*, Midonet C*, Paly E, Barre FX. XerD-mediated FtsK-independent integration of TLCÏ• into the Vibrio cholerae genome. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16848-53. doi: 10.1073/pnas.1404047111. Epub 2014 Nov 10. PMID: 25385643; PMCID: PMC4250166.

  • Das B, Martínez E, Midonet C, Barre FX. Integrative mobile elements exploiting Xer recombination. Trends Microbiol. 2013 Jan;21(1):23-30. doi: 10.1016/j.tim.2012.10.003. Epub 2012 Nov 2. PMID: 23127381

Skills & Proficiency

Microbiome Biotherapeutics AMR Genome-engineering AMR Metagenomics Genomics Bacteria Pathogens Probiotics Sepsis MASLD
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