Profile
Dr. Jomon Joseph has completed his Master's degree in Agriculture with a specialization in Crop Physiology from the University of Agricultural Sciences, Bangalore. He received his PhD in Biochemistry from the Indian Institute of Science, Bangalore, and did post-doctoral research at the National Institutes of Health, Bethesda, USA. He started his independent research career at the National Centre for Cell Science, Pune in 2005. Recognized as a cell biologist, his lab studies specific cellular structures and their functions, and how they are misregulated in diseases. His pioneering work in the field of Annulate Lamellae biology has provided new insights into the functioning of this relatively unknown organelle. He is an elected member of the Guha Research Conference, India and a member of the Molecular Immunology Forum, India, Indian Society for Cell Biology, Society of Biological Chemists, India and Indian Society for Developmental Biologists. He has been awarded many International Travel Fellowships and was a John E. Fogarty International Visiting Fellow.
Current Focus Areas
Cell Biology of Annulate Lamellae (AL): an underexplored cell organelle and its relevance in health and disease.
Biogenesis and functioning of extracellular vesicles
Selected Publications
Sahoo MR, Gaikwad S, Khuperkar D, Ashok M, Helen M, Yadav SK, Singh A, Magre I, Deshmukh P, Dhanvijay S, Sahoo PK, Ramtirtha Y, Madhusudhan MS, Gayathri P, Seshadri V, Joseph J*. Nup358 binds to AGO proteins through its SUMO-interacting motifs and promotes the association of target mRNA with miRISC. EMBO Rep. 2017 Feb;18(2):241-263.
Magre I, Fandade V, Damle I, Banerjee P, Yadav SK, Sonawane M*, Joseph J*. Nup358 regulates microridge length by controlling SUMOylation-dependent activity of aPKC in zebrafish epidermis. J Cell Sci. 2019 Jun 17;132(12):jcs224501. . (Cover page article) (Also selected for First Author interview)
Banerjee P, Markande S, Kalarikkal M, Joseph J*. SUMOylation modulates the function of DDX19 in mRNA export. J Cell Sci. 2022 Feb 15;135(4):jcs259449. (Selected for First Author interview)
Murawala P, Tripathi MM, Vyas P, Salunke A, Joseph J*. Nup358 interacts with APC and plays a role in cell polarization. J Cell Sci. 2009 Sep 1;122(Pt 17):3113-22.
Chavan S, Khuperkar D, Lonare A, Panigrahi S, Bellare J, Rapole S, Seshadri V, Joseph J*. RanGTPase links nucleo-cytoplasmic transport to the recruitment of cargoes into small extracellular vesicles. Cell Mol Life Sci. 2022 Jul 2;79(7):392.