Profile
Dr. Maddika Subba Reddy is leading an independent group at CDFD, where research in his lab (Laboratory of Cell Death and Cell Survival) is focused on exploring the functional protein interaction networks controlled by phosphatase and ubiquitin systems. His group is interested in identifying new protein complexes responsible for normal functioning of the cell as well as human diseases. His lab has mapped several new functions for the components of phosphatase and ubiquitin systems in human cells.
Current Focus Areas
Molecular networks in controlling cellular homeostasis focussed broadly on Phosphatase and Ubiquitin biology
Selected Publications
Tathe P, Chowdary KVSR, Murmu KC, Prasad P, Maddika S. SHP-1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription. EMBO J. 2022; 41(19):e109720.
Kumar P, Tathe P, Chaudhary N, Maddika S. PPM1G forms a PPP-type phosphatase holoenzyme with B56 that maintains adherens junction integrity. EMBO Rep. 2019: e46965.
Shinde SR, Maddika S. PTEN regulates glucose transporter recycling by impairing SNX27 retromer assembly. Cell Reports. 2017, 21(6): 1655-1666.
Shinde SR, Maddika S. PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7. Nature Communications. 2016, 7:10689.
Maddika S, Kavela S, Rani M, Palicherla PV, Chen J. WWP2 is an E3 ubiquitin ligase for PTEN. Nature Cell Biol. 2011; 13(6): 728-33.