Profile
Jan 2024-date Scientist E1, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India July 2020- Dec 2023 Scientist E1, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India Sept 2016-June 2020 DBT-Ramalingaswamy Faculty, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India Oct 2012-Sept 2016 Senior research associate, Chemical Biology with Prof. Hagan Bayley, University of Oxford, UK Jan 2010-Sept 2012 Post-doctoral research associate, Jacobs University Bremen, Germany, collaboration with University of Cambridge
Current Focus Areas
The major interest of my laboratory is the engineering of transmembrane pores for applications in biotechnology and medicine. In particular, we focus on synthetic peptides-derived alpha-helical pores and biological transmembrane pores and explore their biophysical and electrical characterization using single-molecule electrical sensing studies.
Selected Publications
1. Satheesan R, Vikraman D, Jayan P, Vijayan V, Chimerel C, Mahendran KR*. Sensing PEGylated Peptide Conformations Using a Protein Nanopore. Nano Letters, 2024. 2. Das, A. D., K, V., & Mahendran, K. R*. Synthetic α-Helical Nanopore Reactor for Chemical Sensing. JACS Au, 2023. 3(9), 2467-2477. 3. Krishnan RS, Jana K, Shaji A, Nair KS, Das AD, Vikraman D, Bajaj H, Kleinekathöfer K, Mahendran KR*. Assembly of Transmembrane Pores from Mirror-Image Peptides. Nature Communications. 2022. 13 (1), 1-13. 4. Vikraman D, Satheesan R, Kumar KS, Mahendran KR*. Nanopore Passport Control for Substrate Specific Translocation. ACS Nano. 2020. 14(2):2285-2295. 5. Krishnan R S, Satheesan R, Puthumadathil N, Kumar KS, Jayasree P, Mahendran KR*. Autonomously Assembled Synthetic Transmembrane Peptide Pore. Journal of the American Chemical Society. 2019. 141(7):2949-2959.