Profile
Dr. Maiti, a professor at the Regional Centre for Biotechnology, holds a PhD in Chemistry from the Indian Institute of Technology, Kharagpur. He pursued postdoctoral training at the Weizmann Institute of Science (Israel), Purdue University (USA), and the Nagoya Institute of Technology (Japan). His lab focuses on unraveling protein homeostasis mechanisms in various diseases, especially metabolic disorders and neurodegenerative diseases. Moreover, he is a lead investigator in the Group for Advanced Research on Birth Outcome-DBT India Initiative (GARBH-Ini) program, where his lab is actively engaged in developing mass spectrometry-based biomarkers for pregnancy complications, including preterm birth.
Current Focus Areas
Neurodegenerative diseases involve progressive neuronal decline in specific brain areas, driven by abnormal protein aggregates unique to each condition. These aggregates, often triggered by genetic or environmental factors, lead to impaired protein folding. We aim to elucidate their aggregation mechanisms and toxic effects on disease advancement.
Protein metabolism, crucial for cell function, involves synthesis, folding, transport, and degradation. Chaperones aid folding, while proteasomes and autophagy manage degradation. Dysregulation of protein quality control leads to many diseases, including neurodegenerative disorders. Our research focuses on understanding the ubiquitin signaling mechanism in Parkinson’s disease.
Metabolic dysfunction-associated fatty liver disease (MAFLD) encompasses the presence of steatosis, potentially progressing to steatohepatitis and fibrosis. It emerges within an unhealthy metabolic environment and is linked to disruptions in metabolism. Our primary objective revolves around comprehending the intricate dynamics of protein ubiquitination and deubiquitination within MAFLD.
Preterm birth, a significant global health issue, is the primary cause of neonatal mortality. India holds the highest share of preterm births and related deaths (~25%). Our focus lies in mass spectrometry-based proteomics, deciphering protein alterations throughout pregnancy stages to unveil potential biomarkers aiding early preterm birth.
Selected Publications
Majumder S, Srivastava M, Alam P, Saha S, Kumari R, Chand AK, Asthana S, Sen S, Maiti TK (2024) Hotspot site microenvironment in the deubiquitinase OTUB1 drives its stability and aggregation. J Biol Chem:107315. doi: 10.1016/j.jbc.2024.107315.
Saha S, Verma R, Kumar C, Kumar B, Dey AK, Surjit M, Mylavarapu SVS and Maiti TK (2022) Proteomic analysis revealed USP7 as a novel regulator of palmitic acid-induced hepatocellular carcinoma cell death. Cell Death Disease, 13:563.
Kumar B, Dey AK, Saha S, Singh AK, Kshetrapal P, Wadhwa N, Thiruvengadam R, Desiraju BK, Bhatnagar S, Salunke DM, Rashid F, Malakar D, Maiti TK*; GARBH-Ini Study Group (2021) Dynamic Alteration in the Vaginal Secretory Proteome across the Early and Mid-Trimesters of Pregnancy. J Proteome Res. 20:1190.
Kumari R, Kumar R, Kumar S, Singh AK, Hanpude P, Jangir D, Maiti TK. (2020) Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease. J Biol Chem. 295:3466
Kumar R, Kumar S, Hanpude P, Singh AK, Johari T, Majumder, S, Maiti TK (2019) Partially oxidized DJ-1 inhibits primary and secondary nucleation through the adhesive surface and remodels mature α-synuclein fibrils to toxic conformations. Communications Biology, 2: 395