Profile
Dr. Priya Srinivas’ laboratory has made seminal contributions in analyzing the genetic cause of BRCA1 defective cancers, unleashing the possibilities to attenuate the tumor development and identifying potential ways to destroy those cells in a targeted manner for which she has won several National and International accolades, including the ICMR Prem Nath Wahi Award; the American Association of Cancer Research (AACR)-National Cancer Institute (NCI) International Investigator Opportunity Grants, USA; Cancer Prevention Fellowship, National Cancer Institute, National Institutes of Health, USA and ICMR-DHR international Fellowship for Senior Scientist. From RGCB, Dr. Srinivas has published about 50 international peer reviewed studies which has about 2300 citations in total and has an Indian patent and completed over a dozen government funded projects.
Current Focus Areas
1 Analysis of tumor characteristics and therapeutic strategies for β-hCG positive Breast Cancer Patients from Kerala using microfluidic organ-on-a-chip culture device
2 Development of non-invasive tools for early diagnosis of diseases
3 Develop anti-cancer/anti-metastatic strategies for BRCA1 defective triple negative Breast Cancers based on cues from the tumor micro-environment
Selected Publications
1. Geetu Rose Varghese, Dipyaman Patra , Vishnu Sunil Jaikumar, Arathi Rajan, Neetha R Latha and Priya Srinivas: βhCG mediate immune suppression in BRCA1 deficient breast cancers. Immunology, 2023: 1-16; IF : 7.397
2. Arathi Rajan, Geetu R Varghese, Induprabha Yadev, Jaimie Anandan, Neetha R Latha, Dipyaman Patra, Neethu Krishnan, Krithiga Kuppusamy, Arathy V Warrier, Satej Bhushan, Revathy Nadhan, Ram M R K, Priya Srinivas: Modulation of BRCA1 mediated DNA damage repair by deregulated ER-α signaling in breast cancers. Am J Cancer Res 2022;12(1):17-47. IF : 6.166
3. Revathy Nadhan, Jayashree V V, Satheesh K S, Sreelatha K H, C Nirmala, Santha S, P V Aysha, Sreelekha Y, R S Krishnapriya, B V Amritha K, Sreevidya P S, Arathi R, Neetha R L, Geetu R V, Ratheeshkumar T, Sarada A, Dev S U Jithin, T V A Kumar, Priya Srinivas*, BRCA1 promoter hypermethylation in human placenta: A hidden link with β-hCG expression, Carcinogenesis, 2020;41(5):611-624. IF. 5.334.
4. Satheesh K S, Sreelatha K Hemalatha, Revathy N, Thara S, Arun P M, Arkadiusz Chil, Janusz K, Rakesh S Nair, Jerald Mahesh Kumar, Priya Srinivas*, β-hCG-induced mutant BRCA1 ignites drug resistance in susceptible breast tissue. Carcinogenesis. 2019;40(11):1415-1426., IF. 5.334.
5. Satheesh K S, Revathy N, Rakesh S N, Sreelatha K H, Veena S, Reshma R S, Arathi R, Neetha R L, Geetu RV, Ratheeshkumar T, Jerald M K, Arkadiusz Chil, T V Anilkumar, Priya Srinivas*. BRCA1 regulation on β-hCG: A mechanism for tumorigenicity in BRCA1 defective breast cancer. Oncogenesis, 2017 Sep 4;6(9):e376. IF. 5.021