Profile
Debasis Dash is interested in developing algorithms and tools in the area of computational biology. His specific interests are developing novel approaches to to study intrinsically disordered proteins, Proteome Informatics using Mass-spectrometry, Analyse exomes, metagenomes to understand how variations at molecular level contribute to systemic level through ayurgenomics, phenome india - a long-term longitudinal observational cohort study of health outcomes, building deep learning based models for identification of pathological condition type and subtype classification, segmentation and risk score triage, NLP based models for collaborative network recommendation system, His group has developed several tools and algorithms such as GenoCluster - for protein coding gene identification, PLHost - for Protein function assignment, machine learning tool "Pro-Gyan" for protein classification, "MassWiz", "EuGenosuite" and "PgxSAVy" for proteomics etc.
Current Focus Areas
Proteome Informatics using Mass spectrometry, analyze multi omics data to understand how variations at molecular level contribute to systemic level, developing AI/DL models for big data analysis, NLP based models for collaborative network recommendation system
Selected Publications
Raj A, Aggarwal S, Singh P, Yadav AK, Dash D. PgxSAVy: A tool for comprehensive evaluation of variant peptide quality in proteogenomics - catching the (un)usual suspects. Comput Struct Biotechnol J. 2023 Dec 26;23:711-722. doi: 10.1016/j.csbj.2023.12.033. PMID: 38292474; PMCID: PMC10825656. Gupta I, Shankrit S, Narta K, Ghazi M, Grover R, Pandey R, Kar HK, Menon SM, Gupta A, Yenamandra VK, Singh A, Mukerji M, Mukhopadhyay A, Rani R, Gokhale RS, Dash D, Natarajan VT. Whole-Exome Sequencing of Vitiligo Lesions Indicates Lower Burden of Somatic Variations: Implications in Risk for Nonmelanoma Skin Cancers. J Invest Dermatol. 2023 Jun;143(6):1111-1114.e8. Singh P, Ujjainiya R, Prakash S, Naushin S, Sardana V, Bhatheja N, [...], Agrawal A, Sengupta S, Dash D. A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys. Comput Biol Med. 2022 Jul;146:105419. Ujjainiya R, Tyagi A, Sardana V, Naushin S, Bhatheja N, Kumar K, Barman J, Prakash S, Kutum R, [...], Agrawal A, Dash D, Jha S, Sengupta S. High failure rate of ChAdOx1-nCoV19 immunization against asymptomatic infection in healthcare workers during a Delta variant surge. Nat Commun. 2022 Apr 1;13(1):1726. Singh P, Ujjainiya R, Prakash S, Naushin S, Sardana V, [...] Agrawal A, Sengupta S, Dash D. A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys. Comput Biol Med. 2022 Jul;146:105419.