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Profile
I am a Structural Biologist with over 15 years of research experience in studying the interactions of serum proteins with drug/non drug ligands. PhD in Biotechnology from Aligarh Muslim University, post doctoral training at Jawahar Lal Nehru University and working as a faculty in National Institute of Immunology, New Delhi since 2015. I have received Biotechnology Career Advancement and Re-orientation Program for Women Scientists award from Department of Biotechnology, India and Dr. D.S. Kothari Postdoctoral Fellowship award from University Grants Commission, India. My research work broadly emphasizes on understanding the Human serum albumin (HSA), being the most abundant carrier protein in blood and a modern day clinical tool for drug delivery that attracts high attention among biologists. HSA acts as a potential contender for being a molecular cargo or nanovehicle for clinical, biophysical and industrial purposes. My work highlights overview on the ligand (drug/non drug) binding and folding/unfolding strategies of the protein in therapeutics and clinical biochemistry.
Current Focus Areas
1. Elucidating the complicated mechanism of toxin disposition and impaired drug binding in renal disease state. 2. Probing the binding of heavy environmental pollutants which are carcinogenic with human serum albumin, the major transport protein in blood especially for Zn2+ and Cd2+ metal ions
2. Probing the binding of heavy environmental pollutants which are carcinogenic with human serum albumin, the major transport protein in blood especially for Zn2+ and Cd2+ metal ions
Selected Publications
Varshney A; Ansari Y; Zaidi N; Ahmad E, Badr G; Alam P and Khan R.H. (2014) Analysis of Binding Interaction between antibacterial ciprofloxacin and human serum albumin by spectroscopic technique. Cell Biochem. & Biophy.70:93-101
Varshney A; Rehan M; Subbarao N; Rabbani G and Khan RH (2011) Elimination of Endogenous Toxin Creatinine from Blood Plasma: Site specific Uremic Toxicity and Drug binding. Plos One 6: e17230
Varshney A; Sen P; Ahmad E; Rehan M; Subbarao N and Khan RH (2010) Ligand Binding Strategies on Human Serum Albumin: How Can the cargo be Utilized? Chirality 22:77-87
Varshney A; Ahmad B; Rabbani G and Khan RH (2010) Acid Induced Unfolding of Didecameric Keyhole Limpet Hemocyanin: Detection and Characterizations of Decameric and Tetrameric Intermediate States. Amino Acids 39:899-910
Varshney A; Ahmad B and Khan RH (2008) Comparative studies of Unfolding & Binding of ligands to Human serum albumin in the presence of fatty acids: Spectroscopic Approach. Int. J. Biol. Macromol. 42:483-490