Dr. Soma Chattopadhyay

Scientist F, BRIC-ILS

Profile

Dr. Soma Chattopadhyay is an eminent virologist who has worked extensively on several viruses such as the Chikungunya virus (CHIKV), Rotavirus, Herpes Simplex Virus (HSV), Japanese Encephalitis (JEV) and Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For the past 14 years, her lab has been focusing on several broad aspects of CHIKV infection with the attention primarily being the understanding of basic mechanisms of Chikungunya virus replication and identification of host factors involved during the process of infection. Beside that her group is working on various Antiviral molecules (Drug repurposing, small molecules and natural extracts) for their in vitro antiviral activity that could further potentially be assessed in vivo and ultimately aid in the acceleration of a drug’s market entry.

Current Focus Areas

  • Identification of novel Host factors for CHIKV and SARS-CoV-2 pathogenesis

  • High throughput antiviral screening platform the discovery of novel antivirals and board-spectrum antivirals

  • Advanced Mass Spectrometry platform for performing discovery proteomics, metabolomics and lipidomics

Selected Publications

  • Chatterjee, S., Ghosh, S., Datey, A., Mahish, C., Chattopadhyay, S., & Chattopadhyay, S. (2023). Chikungunya virus perturbs the Wnt/β-catenin signaling pathway for efficient viral infection. Journal of virology, 97(11), e0143023. https://doi.org/10.1128/jvi.01430-23

  • Mahish, C., De, S., Chatterjee, S., Ghosh, S., Keshry, S. S., Mukherjee, T., Khamaru, S., Tung, K. S., Subudhi, B. B., Chattopadhyay, S., & Chattopadhyay, S. (2023). TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages. Frontiers in immunology, 14, 1139808. https://doi.org/10.3389/fimmu.2023.1139808

  • Chatterjee, S., Kumar, S., Mamidi, P., Datey, A., Sengupta, S., Mahish, C., Laha, E., De, S., Keshry, S. S., Nayak, T. K., Ghosh, S., Singh, S., Subudhi, B. B., Chattopadhyay, S., & Chattopadhyay, S. (2022). DNA Damage Response Signaling Is Crucial for Effective Chikungunya Virus Replication. Journal of virology, 96(23), e0133422. https://doi.org/10.1128/jvi.01334-22

  • De, S., Ghosh, S., Keshry, S. S., Mahish, C., Mohapatra, C., Guru, A., Mamidi, P., Datey, A., Pani, S. S., Vasudevan, D., Beuria, T. K., Chattopadhyay, S., Subudhi, B. B., & Chattopadhyay, S. (2022). MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo. Antimicrobial agents and chemotherapy, 66(7), e0046322. https://doi.org/10.1128/aac.00463-22

  • Singh, B., Avula, K., Chatterjee, S., Datey, A., Ghosh, A., De, S., Keshry, S. S., Ghosh, S., Suryawanshi, A. R., Dash, R., Senapati, S., Beuria, T. K., Prasad, P., Raghav, S., Swain, R., Parida, A., Hussain Syed, G., & Chattopadhyay, S. (2022). Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India. Frontiers in microbiology, 13, 856913. https://doi.org/10.3389/fmicb.2022.856913

Skills & Proficiency

Virus infection Replication Pathogenesis Epidemiology Host factors antivirals Drugs Repurposing Therapeutics Proteomics
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