Profile
Dr. Rashmi Mishra obtained her PhD in Neuroscience from the National Brain Research Centre (NBRC), Manesar, India. She did her postdoctoral studies in the Biomembrane Laboratory of Prof. Kai Simons at the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. After a brief stint in the Mechanobiology Laboratory at the Curie Institute, Paris, France, she joined BRIC-RGCB as group leader and Ramalingaswami Fellow in the Dept. of Neurobiology. She has obtained grants from DBT, ICMR and CSIR. Her current area of research focuses on identifying and developing novel, stable and cost-effective biomarkers for early diagnosis of fatal diseases, as well as formulation of rationale phytodrugs-based therapeutics for the same.
Current Focus Areas
Our major goal is to understand 'how cells sense and respond to the mechanical microenvironment' with a therapeutic implications to cancers, neuro and cardio degenerative diseases as well as abnormal aging by engaging physico-chemical assays and multi-omics analysis, relevant animal models and patients' samples for the examination of clinical relevance
Selected Publications
1.Gayathri K.G., Puja Laxmanrao Shinde, Sebastian John, Sivakumar K. C., and Rashmi Mishra*.(2023).Understanding the Combined Effects of High Glucose Induced Hyper- Osmotic Stress and Oxygen Tension in the Progression of Tumourigenesis: From Mechanism to Anti- Cancer Therapeutics. Cells, 7 March 2023, 12, no. 6: 825. https://doi.org/10.3390/cells12060825. (Impact factor: 7.666) *Corresponding author
2.Sebastian John, K.G, Gayathri, Krishna, AP, Rashmi Mishra* (2022). Neurotherapeutic implications of sense and respond strategies generated by astrocytes and astrocytic tumours to combat pH mechanical stress. Neuropathology and Applied Neurobiology. DOI:10.1111/nan.12774 (Impact factor: 8.090, CiteScore 11.5) *Corresponding author
3.Krishna, A.P., Sebastian John, Shinde, P.L. and Rashmi Mishra* (2021). Proteo- transcriptomics meta-analysis identifies SUMO2 as a promising target in glioblastoma multiforme therapeutics. Cancer Cell International,21,575. DOI: 10.1186/s12935-021-02279-y (Impact factor: 6.72) *Corresponding author
4. Rashmi Mishra*, M Grzybek, T Niki, M Hirashima, K Simons (2010). Galectin-9 trafficking regulates apical-basal polarity in Madin–Darby canine kidney epithelial cells. Proceedings of the National Academy of Sciences; 107 (41), 17633-17638, https://doi.org/10.1073/pnas.1012424107 (Impact factor:11.2) *First author
5.SK Gupta*, Rashmi Mishra*, S Kusum, M Spedding, KF Meiri, P Gressens, S Mani (2009. GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986. Cell Death & Differentiation; 16 (4), 624-637,2009, 10.1038/cdd.2008.188 (Impact factor:15.82) *Equal First author