Profile
Devyani Haldar obtained her M.Sc. (Biotechnology) from JNU, Delhi and Ph.D. (Biochemistry) from the IISc, Bangalore. During Ph.D., she purified a structure-specific endonuclease from rat testis and showed it functions in processing of DNA replication and repair intermediates. She worked on deciphering biological functions of the Sirtuin family NAD-dependent protein deacetylases at the National Institutes of Health (NIH), USA as post-doctoral fellow. Her work on fission yeast Sirtuin showed, Hst4 deacetylates, Histone H3 lysine 56 acetylation, a novel histone modification and this deacetylation is required for DNA damage signaling. Currently, she is the head of the Laboratory of Chromatin Biology and Epigenetics at the Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad. Her research group is working towards understanding functions and regulation of chromatin modifications and regulators in DNA replication, replication stress response and repair and contribution of these mechanisms to maintenance of genomic integrity and implication in cancer progression.
Current Focus Areas
Understanding mechanisms that main genomic integrity. Mechanisms of DNA replication and repair in chromatin context by studying dynamic changes in chromatin structure and regulator. Interaction of mTORC complexes and sirtuins in metabolic reprogramming in glioblastoma
Selected Publications
Shanili Aricthota and Devyani Haldar (2021) DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks. eLife 10:e70787.
Raghavendra Vadla and Devyani Haldar (2018) Mammalian target of rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation. Cell cycle 17:110-123.
Amrita Sengupta and Devyani Haldar (2018) Human Sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote Nonhomologous end joining repair. DNA Repair 61; 1-16.
Rahul Kumar Vempati, Ranveer Jayani, Notani D., Amrita Sengupta, Galande S and Devyani Haldar*(2010) p300 mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammalsJ. Biol. Chem. 285 (37), 28553-28564.
Ananga Ghosh, Amrita Sengupta, Guru Pavan Kumar Seerapu, Ali Nakhi, E. V. Venkat Shivaji Ramarao, Navneet Bung, Gopalakrishnan Bulusu, Manojit Pal and Devyani Haldar. A novel SIRT1 inhibitor, 4bb induces p53-dependent apoptosis in HCT116 human colon carcinoma cells. (2017) Biochem. Biophys. Res. Commun. 488(3):562.