.png)
Profile
Mitochondria-derived vesicles act as a first line of defence in response to mitochondrial insults, which precedes mitophagy. Our lab is interested in understanding the molecular pathways of MDV biogenesis and trafficking to other organelles. By mapping the trafficking itinerary of this class of ancient vesicles, we hope to understand how endosymbiosis forged the development of eukaryotic endomembranes. Further, increasing the mito-protective release of MDVs in cardiac diseases could stall the progress of several cardiovascular diseases characterised by mitochondrial dysfunction.
Current Focus Areas
Mitochondria-derived Vesicles and mito-nuclear communication
Actin cytoskeletal remodelling and mitochondrial quality in Angiogenesis
Moyamoya Angiopathy
Selected Publications
Nidhi Nair, Victor Samuel, Lariza Ramesh, Areeba Marib and Ananthalakshmy Sundararaman*, Actin Cytoskeleton in Angiogenesis, Biology Open, (2022), 11 (12): bio058899
Ananthalakshmy Sundararaman, Yoko Fukushima, Jim C. Norman, Akiyoshi Uemura and Harry Mellor, RhoJ regulates α5β1 integrin trafficking to control fibronectin remodelling during angiogenesis; Current Biology (2020), 30, 1-10
Ananthalakshmy Sundararaman, Usha Amirtham and Annapoorni Rangarajan, Calcium-Oxidant Signaling Network Regulates AMPK Activation Upon Matrix-deprivation,Journal of Biological Chemistry, (2016) 291, pp14410-29.
Nidhi Nair, Lariza Ramesh, Areeba Marib, Thejaswitha Rajeev, and Ananthalakshmy Sundararaman; In Vitro Budding and Floatation based Enrichment of Mitochondria-derived Vesicles for Proteomics, bioRxiv, 2024.03. 04.583262
Rajeev, T.; Shil, D.; Bhattacharjee, S.; Ramesh, L.; Samuel, V.; Nair, N. Y.; Marib, A.; Jayakumar, M.; Surendran, A.; Sundararaman, A. (2024)Mitochondria-derived Vesicles mediate Mito-nuclear Trafficking of Cargo bioRxiv, 2024.05.04.592299