Profile
The laboratory's primary objective is to exploit clues derived from research conducted during pre- and post-implantation development to gain insights into disorders including pre-eclampsia, leukemia, and breast cancer. These cues are being utilized to develop more effective methods for disease detection, assessment of new biomarkers, and the creation of therapeutic interventions.
Current Focus Areas
Histone epigenetic in defects of pre- and post-implantation of embryo and pre-eclampsia
Regulation of chromatin architecture in hematopoiesis vs leukemogenesis
Stem cells and centrosome
Evaluation of histone epigenetic factors as biomarkers for breast cancer and pre-eclampsia
Biomanufacturing- cultivated meat as smart protein
Selected Publications
Varghese, P.C., Rajam, S. M., Nandy, D., Jory, A., Mukherjee, A., Dutta D. (2021). Histone chaperone APLF level dictate implantation of mouse embryo. J. Cell Sci. 134(1), jcs246900.
Baral I, Shirude MB, Jothi DL, Mukherjee A, Dutta D. (2023). Characterization of a Distinct State in the Continuum of Pluripotency Facilitated by Inhibition of PKCĪ¶ in Mouse Embryonic Stem Cells. Stem Cell Rev Rep, 19(4), 1098-1115
Majumder, A., Syed, K. M., Mukherjee, A., Lankadasari, M. B., Azeez, J. M., Sreeja, S., Harikumar, K. B., Pillai, M. R. & Dutta, D. (2018). Enhanced expression of histone chaperone APLF associate with breast cancer. Mol Cancer, 17(1), 76
Syed, K. M., Joseph, S., Mukherjee, A., Majumder, A., Teixeira, J. M., Dutta, D., & Pillai, M. R. (2016). Histone chaperone APLF regulates induction of pluripotency in murine fibroblasts. J Cell Sci, 129(24), 4576-4591.
Majumder, A., Syed, K. M. & Joseph, S., Scambler, P. J. & Dutta, D. (2015). Histone Chaperone HIRA in Regulation of Transcription Factor RUNX1. J Biol Chem, 290(21), 13053-13063.