Profile
Dr. Girish K. Radhakrishnan obtained MSc in Microbiology (1999) from School of Biosciences, Mahatma Gandhi University, Kerala and PhD in Biotechnology (2006) from School of Biotechnology, Madurai Kamaraj University, Tamil Nadu. He did his postdoctoral research (2006-2010) at the University of Wisconsin-Madison, USA and worked as Research Assistant Professor at the same university (2010-2012). He joined NIAB on 03 December 2012.
Current Focus Areas
I am studying brucellosis, caused by the facultative intracellular bacterial pathogen Brucella. Limited information is available on the bacterial and host factors that contribute to Brucella's invasion and intracellular persistence. My research focuses on understanding the virulence mechanisms of Brucella, to develop improved vaccines and therapeutics for brucellosis.
Selected Publications
Sushree Rekha Mallik, Kiranmai Joshi and Girish K Radhakrishnan* (2024). The arginine/ornithine-binding protein ArgT plays an essential role in Brucella to prevent intracellular killing and contribute to chronic persistence in the host. Virulence 2024 Dec;15(1):2421983. doi: 10.1080/21505594.2024.2421983.
Kiranmai Joshi, Varadendra Mazumdar, Binita Roy Nandi, Girish K Radhakrishnan* (2024). Brucella targets the host ubiquitin-specific protease, Usp8, through the effector protein, TcpB, for facilitating infection of macrophages. Infection and Immunity, 4 January 2024, e0028923. doi: 10.1128/iai.00289-23.
Subathra Murugan, Binita Roy Nandi, Varadendra Mazumdar, Kiranmai Joshi, Prachita Nandini, Swapna Namani, Padmaja Jakka, Girish K Radhakrishnan* (2023). Outer membrane protein 25 of Brucella suppresses TLR-mediated expression of proinflammatory cytokines through degradation of TLRs and adaptor proteins. Journal of Biological Chemistry 299 (11).
Prachita Nandini, Padmaja Jakka, Subathra Murugan, Varadendra Mazumdar, Deepak Kumar, Richa Prakash, Sukhadeo B. Barbuddhe and Girish Radhakrishnan* (2023) Immuno-profiling of Brucella proteins for developing improved vaccines and DIVA capable serodiagnostic assays for brucellosis. Front. Microbiol. Volume 14 – 2023.
Varadendra Mazumdar, Kiranmai Joshi, Binita Roy Nandi, Swapna Namani, Vivek Kumar Gupta and Girish Radhakrishnan* (2022). Host F-Box Protein 22 Enhances the Uptake of Brucella by Macrophages and Drives a Sustained Release of Proinflammatory Cytokines through Degradation of the Anti-Inflammatory Effector Proteins of Brucella. Infection and Immunity 2022 May 19;90(5):e0006022.
Subathra Murugan, Padmaja Jakka, Swapna Namani,Varadendra Mujumdar and Girish Radhakrishnan* (2019). The neurosteroid, pregnenolone promotes degradation of key proteins in the innate immune signalling to suppress inflammation. Journal of Biological Chemistry 294 (12) 4596-4607.
Padmaja Jakka, Swapna Namani, Subathra Murugan, Nivedita Rai and Girish Radhakrishnan* (2018). The Brucella effector protein TcpB induces degradation of inflammatory caspases and thereby subverts non-canonical inflammasome activation in macrophages. Journal of Biological Chemistry 292 (50), 20613-20627
Padmaja Jakka, Bindu Bhargavi, Swapna Namani, Subathra Murugan, Gary Splitter and Girish Radhakrishnan* (2017). Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP. Journal of Immunology 200 (2) 704-714.