Ramesh Pothuraju

Scientist C, BRIC-RGCB

Profile

My laboratory is currently focused on gaining a deeper understanding of the role played by the intestinal mucus layer and how alterations in the gut microbiota contribute to the development of CRC and therapy resistance. Our research employs a combination of in vitro and in vivo pre-clinical studies to explore these intricate interactions. Ultimately, our goal is to uncover potential therapeutic strategies to address both the disruptions in the intestinal mucus layer and the altered gut microbiota, which are associated with therapy resistance in this context.

Current Focus Areas

  • 1. Understand the role of mucins in colorectal cancer progression and therapy resistance

  • 2. Dietary fiber role in obesity associated colorectal cancer

Selected Publications

  • Pothuraju R*, Khan I*, Jain M, Bouvet M, Malafa M, Roy HK, Kumar S, Batra SK. Colorectal cancer murine models: Initiation to metastasis. Cancer Letters. 2024, doi: 10.1016/j.canlet.2024.216704. (IF: 9.7)

  • Pothuraju R, Pai P, Chaudhary S, Siddiqui JA, Cox JL, Kaur S, Rachagani S, Roy HK, Bouvet M and Batra SK. Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer. Aging. 2022, 14(5):2025-2046. doi: 10.18632/aging.203935

  • Pothuraju R, Rachagani S, Krishn SR, Chaudhary S, Nimmakayala RK, Siddiqui JA, Ganguly K, Lakshmanan I, Cox JL, Mallya K, Kaur S, Batra SK. Molecular implications of MUC5ACCD44 axis in colorectal cancer progression and chemoresistance. Mol Cancer. 2020, 19(1):37. doi: 10.1186/s12943-020-01156-y

  • Ganguly K, Krishn SR, Rachagani S, Jahan R, Shah A, Nallasamy P, Rauth S, Atri P, Cox JL, Pothuraju R, Smith LM, Ayala S, Evans C, Ponusamy MP, Kumar S, Kaur S, Batra SK. Secretory mucin 5AC promotes neoplastic progression by augmenting KLF4-mediated pancreatic cancer cell stemness. Cancer Res. 2020 81(1):91-102, doi: 10.1158/0008-5472.CAN-20-1293

  • Chugh S, Barkeer S, Rachagani S, Nimmakayala RK, Perumal N, Pothuraju R, Atri P, Mahapatra S, Thapa I, Talmon GA, Smith LM, Yu X, Neelamegham S, Fu J, Xia L, Ponnusamy MP, Batra SK. Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice. Gastroenterology. 2018;155(5):1608-24, doi: 10.1053/j.gastro.2018.08.007

Skills & Proficiency

Obesity Gut Microbiota Prebiotics Probiotics Dietary Fiber Intestinal Homeostasis Mucins Colorectal Cancer Pancreatic Cancer Chemoresistance
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