Profile
Dr. Tailor got his PhD degree from Cancer Research Institute (now ACTREC, Navi Mumbai) in the area of Virology/Oncology. He got his post-doctoral training under Dr. keiko Ozato (NICHD/NIH, USA) in the area of Dendritic cell (DC) biology and established Laboratory of Innate immunity at NII, New Delhi after returning to India. Dr. Tailor has received Ramalingaswami Fellowship from DBT, Govt. of India and also recipient of mid-career scientist award from Indian Immunology Society in year 2019. His laboratory focuses on understanding the role of Interferon Regulatory Factors in dendritic cell development and understanding the role of DCs in various infectious and autoimmune as well life style disorders.
Current Focus Areas
Dendritic cells (DC) are collection of populations broadly categorized into plasmacytoid DCs and classical DCs represented by cDC1(CD8+/CD103+CD11b−SIRP−) and cDC2(CD4+/CD103−CD11b+SIRP+). Laboratory is focused towards understanding mechanisms of IRF directed DC development and cross talk of IRFs, transcription factors and signaling pathways. Autoimmune disorders, microbial infection, cancer biology are other areas.
Selected Publications
1.Singh Rawat B, Venkataraman R, Budhwar R, Tailor P. Methionine- and Choline- Deficient Diet Identifies an Essential Role for DNA Methylation in Plasmacytoid Dendritic Cell Biology. J Immunol. 2022. doi: 10.4049/jimmunol.2100763
2. Verma R, Jaiswal H, Chauhan KS, Kaushik M and Tailor P* (2016) ACVRL1 signaling augments CD8α+ dendritic cell development. Cuttting Edge: J Immunology 197: 1129-1134. * Corresponding author
3. Jaiswal H, Kaushik M, Sougrat R, Gupta M, Dey A, Verma R, Ozato K, Tailor P. Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development. J Immunol. 2013. doi: 10.4049/jimmunol.1203541.
4. Tailor P, Tamura T, Morse HC 3rd, Ozato K. The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse. Blood. 2008. doi: 10.1182/blood-2007-07-100750.
5. Tailor P, Tamura T, Kubota M, Borghi P, Gabriele L, Ozato K. The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8. Immunity. 2007. doi: 10.1016/j.immuni.2007.06.009.