Profile
Dr Manna's research work focusses on the understanding the molecular mechanism of Profilin for its tumor suppressive activity and thus, induction of it by therapeutic molecules has huge potential to regulate tumor especially in combination chemotherapy. His lab is also interested to understand the molecular mechanism(s) of several deleterious effects (like obesity, diabetes, neurodegeneration, ageing, etc.) mediated by advanced glycation endproducts (AGE) and its regulation ex vivo and in vivo. Beside these, some of the ideas focusses on the regulation bone degeneration and arthritic responses and its regulation.
Current Focus Areas
To establish the molecular mechanism of Profilin as a tumor suppressor and tested its efficacy in combination chemotherapy to suppress tumor in vivo. Understanding the Advanced glycation endproducts (AGE) mediated deleterious effects, like diabetes, obesity, neurodegeneration, ageing, etc. by herbal and synthetic derivatives and tested its efficacy for potential therapeutics.
Selected Publications
1.Saurav, S. and Manna, S.K. (2022). Profilin upregulation induces autophagy through stabilization of AMP-activated protein kinase. FEBS Letters 596: 1765-1777. 2.Saurav, S. and Manna, S.K.. (2022). Increased expression of Profilin potentiates chemotherapeutic agent-mediated tumour regression. British Journal of Cancer 126: 1410–1420. 3. Zaidi, A.H. and Manna, S.K. (2016) Profilin-PTEN interaction suppresses NF-kappa B activation via inhibition of IKK phosphorylation. Biochemical Journal. 473: 859-872. 4. Verma, N. and Manna, S.K. (2016) Advanced Glycation End Products (AGE) Potently Induce Autophagy through Activation of RAF Protein Kinase and Nuclear Factor κB (NF-κB). Journal of Biological Chemistry 291: 1481-1491. 5. Mahali, S., Raviprakash, N., Raghavendra, P.B., Manna S.K. (2011) Advanced glycation end products (AGE) induce apoptosis via a novel pathway: involvement of Ca2+ mediated by interleukin-8. Journal of Biological Chemistry 286: 34903-34913.