Profile
The laboratory uses an integrated evolutionary bioinformatics platform to understand disease biology with particular focus on better understanding of origin, adaptation, transmission and evolution of pathogenicity and antibiotic-resistance among microbes in a wide variety of environments
Current Focus Areas
Evolutionary of antibiotic resistance in Gram Positive priority pathogens, Computer aided drug discovery of novel targets and synergies to combat AMR
Selected Publications
Shijulal Nelson-Sathi, Filipa L Sousa, Mayo Roettger, Nabor Lozada-Chávez, Thorsten Thiergart, Arnold Janssen, David Bryant, Giddy Landan, Peter Schönheit, Bettina Siebers, James O McInerney, William F Martin. (2015). Origins of major archaeal clades correspond to gene acquisitions from bacteria, 517, 7532, 77–80
Ku C, Nelson-Sathi S, Roettger M, Sousa FL, Lockhart PJ, Bryant D, Hazkani-Covo E, McInerney JO, Landan G, Martin WF (2015) Endosymbiotic origin and differential loss of eukaryotic genes. Nature 524:427-432.
Jiffy John, Sinumol George, Sai Ravi Chandra Nori, Shijulal Nelson-Sathi (2019), Phylogenomic Analysis Reveals the Evolutionary Route of Resistant Genes in Staphylococcus aureus, Genome Biol. Evol. 11(10):2917–2926
Roshny Prasad, Anil Kadam, Vinitha Vinod Padippurackal, Aparna Pulikuttymadom Balasubramanian, Naveen Kumar Chandrakumaran, Kartik Suresh Rangari, Pawan Dnyaneshwar Khangar, Harikrishnan Ajith, Kathiresan Natarajan, Rajesh Chandramohanadas, Shijulal Nelson-Sathi (2024), Discovery of small molecule entry inhibitors targeting the linoleic acid binding pocket of SARS-CoV-2 spike protein. Journal of Biomolecular Structure and Dynamics, 1–15.