Profile
Our group is interested in understanding the mechanism of disease pathogenesis behind major intracellular parasites using advance biotechnology tools. The major intracellular pathogens which we are studying are livestock related haemoprotozoan parasites and mastitis causing bacterial pathogens. The focus is to identify and characterize the genes involved in Host Parasite Interactions/Virulence/Drug resistance that could lead to development of tools/strategies for controlling the disease. We are also working on the global problem of antibiotic resistance, which equally effects animal and humans and is a global threat of increasing concern. We are focusing on surveillance of AMR pathogens, understanding antibiotic resistance mechanism, identifying new drug targets and repurposing of the available drugs.
Current Focus Areas
At NIAB, we focus on unraveling the molecular mechanisms driving disease pathogenesis in key intracellular parasites and mastitis-related bacteria. Our goal is to innovate drugs, vaccines, and diagnostics, advancing livestock infectious disease comprehension and fostering novel intervention strategies crucial for disease control in livestock.
We are also working on the global problem of antibiotic resistance, which equally effects animal and humans and is a global threat of increasing concern. We are focusing on surveillance of AMR pathogens, understanding antibiotic resistance mechanism, identifying new drug targets and repurposing of the available drugs.
decipher the role of Epigenetics in driving disease pathogenesis in apicomplexan parasites .
Selected Publications
Madhumanti Barman, Debabrata Dandasena, Akash Suresh, Vasundhra Bhandari, Sonam Kamble, Sakshi Singh, Madhusmita Subudhi, Paresh Sharma. Artemisinin derivatives induce oxidative stress leading to DNA damage and caspase-mediated apoptosis in Theileria annulata transformed cells. Cell Commun Signal. 2023 17;21(1):78. doi: 10.1186/s12964-023-01067-7.
Sonti Roy, V Bhandari, Madhumanti Burman, Pankaj Kumar, Vandna bhanot, JS Arora, Satprakash Singh, Paresh Sharma. Population Genetic analysis of the Theileria annulata parasites identified limited diversity and multiplicity of Infection in the Vaccine from India. Frontiers in Microbiology. 20 January 2021
https://doi.org/10.3389/fmicb.2020.579929.
Umarani Brahma, Akash Suresh, Shweta Murthy, Vasundhra Bhandari, Paresh Sharma. Antibiotic Resistance and Molecular Profiling of the Clinical Isolates of Staphylococcus aureus causing Bovine Mastitis from India. Microorganisms. (2022)
Vasundhra Bhandari, Shalini Chakraborty, Umarani Brahma, Paresh Sharma. Identification of Anti-staphylococcal and Anti-biofilm Compounds by Repurposing the Medicines for Malaria Venture Pathogen Box. Front Cell Infect Microbiol. 2018; 8: 365. Published online 2018 Oct 23. doi: 10.3389/fcimb.2018.00365.
S Chakraborty, S Roy, H Mistry, N George, S Murthy, V Bhandari, P Sharma. Potential Sabotage of Host Cell Physiology by Apicomplexan Parasites for Survival Benefits. (2017) Frontiers of Immunology; 8:1261.