Profile
Trained in Stem cells and developmental biology. Expertise in pluripotent stem cells based disease modelling.
Current Focus Areas
Human iPSCs based Neurological disease modeling
Selected Publications
Sharma, V., Nehra, S., Do, L.H., Ghosh, A., Deshpande, A.J., and Singhal, N. (2022). Biphasic cell cycle defect causes impaired neurogenesis in down syndrome. Front Genet 13, 1007519. 10.3389/fgene.2022.1007519.
Singhal, N., Graumann, J, Wu, G., Bravo, MJA., Han, DW., Greber, B., Gentile, L., Mann, M., and Schöler, HR. (2010). Chromatin Remodeling Components of the BAF Complex Facilitate Reprogramming. Cell 141, 943-955
Wu, W., Han, D., Gong, Y., Sebastiano, V., Gentile, L., Singhal, N., Adachi, K., Fischedick, G., Ortmeier, C., Sinn, M., Radstaak, M., Tomilin, A., Schöler, HR (2013) Establishment of Totipotency does not depend on Oct4. Nature Cell Biology. 15, 1089-1097.
Belichenko, PV.,*# Madani, R.,# Rey-Bellet, L., Pihlgren,M., Becker, A., Plassard, A., Vuillermot, S., Giriens, V., Nosheny, RL., Kleschevnikov, AM., Valletta, JS., Bengtsson, S., Linke, GR., Maloney, MT., Hickman, DT., Reis, P., Granet, A., Mlaki, D., Lopez-Deber, MP., Do, L., Singhal, N., Masliah, E Pearn, ML., Pfeifer, A., Muhs, A., * Mobley, WC., (2016) An anti-β-Amyloid Vaccine for Treating Cognitive Deficits in Down Syndrome. PLOS ONE 11 (3) e0152471
Nehra, S., Sharma, V., Umrani, M., and Singhal, N. (2023). Generation of integration-free Down syndrome and isogenic euploid human induced pluripotent stem cells. Stem Cell Res 67, 103041. doi: 10.1016/j.scr.2023.103041.