Profile
I am a group leader at ICGEB, New Delhi with more than decade of experience and expertise in human immunity. During my tenure, I successfully created and sustained long-term collaborations with clinicians and basic researchers in India and also worked closely with the Emory faculty to develop the capacity, knowledge, and technical know-how to pose fundamental questions about the nature, scope, and mechanisms by which immune profiles affect human disease outcome. I also established many crucial techniques and assays in the lab that allowed analysis of human T and B cell responses including the human monoclonal antibody platform. These efforts have resulted identification and characterizations of many human monoclonal antibodies to Dengue virus, Chikungunya virus and SARS-CoV-2. of a broadly neutralizing SARS-CoV-2 antibody that is further being explored for pre-clinical development. As a full-time faculty member of ICGEB, I also instruct and mentor graduate and master's students who are vital to efforts to enhance human immunology capacity.
Current Focus Areas
Human Immunology, Infectious Diseases
Selected Publications
Aggarwal C, Ahmed H, Sharma P, Reddy ES, Nayak K, Singla M, Maheshwari D, Chawla YM, Panda H, Rai RC, Gunisetty S, Priyamvada L, Bhaumik SK, Ahamed SF, Vivek R, Bhatnagar P, Singh P, Kaur M, Dixit K, Kumar S, Gottimukkala K, Saini K, Bajpai P, Sreekanth GP, Mammen S, Rajan A, Verghese VP, Abraham AM, Shah P, Alagarasu K, Yu T, Davis CW, Wrammert J, Ansari A, Antia R, Kabra SK, Medigeshi GR, Ahmed R, Lodha R, Shet A, Chandele A, Murali-Krishna K. Severe disease during both primary and secondary dengue virus infections in pediatric populations. Nat Med. 2024 Mar;30(3):670-674. doi: 10.1038/s41591-024-02798-x. Epub 2024 Feb 6. PMID: 38321219.
Singh P, Bajpai P, Maheshwari D, Chawla YM, Saini K, Reddy ES, Gottimukkala K, Nayak K, Gunisetty S, Aggarwal C, Jain S, Verma C, Singla P, Soneja M, Wig N, Murali-Krishna K, Chandele A. Functional and transcriptional heterogeneity within the massively expanding HLADR+CD38+ CD8 T cell population in acute febrile dengue patients. J Virol. 2023 Nov 30;97(11):e0074623. doi: 10.1128/jvi.00746-23. Epub 2023 Oct 19. PMID: 37855600; PMCID: PMC10688317.
Patel A, Kumar S, Lai L, Keen M, Valanparambil R, Chakravarthy C, Laughlin Z, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Davis CW, Wrammert J, Sharma A, Ahmed R, Suthar MS, Murali-Krishna K, Chandele A, Ortlund E. Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against Omicron. Cell Rep. 2023 Sep 26;42(9):113150. doi: 10.1016/j.celrep.2023.113150. Epub 2023 Sep 13. PMID: 37708028; PMCID: PMC10862350.
Kumar S, Patel A, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Davis-Gardner ME, Edara VV, Linderman S, Nayak K, Dixit K, Sharma P, Bajpai P, Singh V, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Mantus G, Goel PK, Rahi M, Davis CW, Wrammert J, Godbole S, Henry AR, Douek DC, Suthar MS, Ahmed R, Ortlund E, Sharma A, Murali-Krishna K, Chandele A. Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody. Sci Adv. 2022 Oct 7;8(40):eadd2032. doi: 10.1126/sciadv.add2032. Epub 2022 Oct 5. PMID: 36197988; PMCID: PMC9534492.
Maheshwari D, Saini K, Singh P, Singla M, Nayak K, Aggarwal C, Chawla YM, Bajpai P, Kaur M, Gunisetty S, Eberhardt CS, Nyodu R, Moore K, Suthar MS, Medigeshi GR, Anderson E, Lodha R, Kabra SK, Ahmed R, Chandele A, Murali-Krishna K. Contrasting behavior between the three human monocyte subsets in dengue pathophysiology. iScience. 2022 May 10;25(6):104384. doi: 10.1016/j.isci.2022.104384. PMID: 35620424; PMCID: PMC9127603.