Dr. Arvind Sahu

Executive Director, RCB

Profile

He holds a PhD from Vallabhbhai Patel Chest Institute, University of Delhi, Delhi. He completed his MSc in Microbiology from Nagpur University, Nagpur, and pursued post-doctoral training at the University of Pennsylvania, Philadelphia, Pennsylvania, and the University of Texas Health Science Center at Tyler, Texas.

Current Focus Areas

  • Our lab delves into virus-immune system dynamics, focusing on viral inhibition of the complement system (e.g., Kaposica from Kaposi’s sarcoma-associated herpesvirus) and the role of complement in viral defense, notably against influenza A(H1N1)2009. We employ in vivo and in vitro approaches for deeper insights.

Selected Publications

  • Shende, R., Wong, S.S.W., Meitei, H.T., Lal, G., Madan, T., Aimanianda, V., Pal J.K., Sahu, A. (2022) Protective role of host complement system in Aspergillus fumigatus infection. Front. Immunol. 13:978152.

  • Ghate, A., Sharma, S., Agrawal, P. and Sahu, A. (2021) Differential expression of complement receptors CR1/2 and CR4 by murine M1 and M2 macrophages. Mol. Immunol., 137: 75-83. PMID: 34229135 DOI: 10.1016/j.molimm.2021.06.003

  • Panwar, H.S., Ojha, H., Ghosh, P., Barage, S.H., Raut, S. and Sahu, A. (2019) Molecular engineering of an efficient four-domain DAF-MCP chimera reveals the presence of functional modularity in RCA proteins, Proc. Natl. Acad. Sci. USA., 116(20): 9953-9958. PMID: 31036650 DOI: 10.1073/pnas.1818573116

  • Ojha, H., Ghosh, P., Panwar, H.S., Shende, R., Gondane, A., Mande, S.C. and Sahu, A. (2019) Spatially conserved motifs in complement control protein domains determine functionality in regulators of complement activation-family proteins, Commun. Biol., 2:290: 1-12. DOI: 10.1038/s42003-019-0529-9

  • Rattan, A., Pawar, S.D., Nawadkar, R., Kulkarni, N., Lal, G., Mullick, J., and Sahu, A. (2017) Synergy between the classical and alternative pathways of complement is essential for conferring effective protection against the pandemic influenza A(H1N1) 2009 virus infection, PLoS Pathog, 13(3): 1-26. PMID: 28301559 DOI: 10.1371/journal.ppat.1006

Skills & Proficiency

Complement system Virology Immune evasion Innate immunity Kaposis sarcoma-associated herpesvirus RCA homolog Kaposica Innate immunity Adaptive immunity Herpesvirus Viral pathogenesis Pandemic influenza A(H1N1)2009 Anaphylatoxin signalling Immunological basis
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