Profile
Dr. Sivaram V S Mylavarapu is a distinguished Professor with a PhD earned in 2001 from the National Institute of Immunology. Following this, he conducted postdoctoral research at the University of Massachusetts Medical School, USA. As a Professor, Dr. Mylavarapu contributes significantly to the field of immunology with a focus on innovative research and academic leadership. His expertise encompasses various aspects of immunological research, including but not limited to, immune system regulation, host-pathogen interactions, and immunotherapy development. With a robust background in both academia and research, Dr. Mylavarapu is dedicated to advancing knowledge and fostering scientific inquiry. Through his mentorship and scholarly contributions, he inspires the next generation of scientists and continues to make impactful contributions to the field of immunology.
Current Focus Areas
We aim to uncover therapeutic targets for disease intervention. Motivated recent PhDs in life sciences are encouraged to apply for postdoctoral positions, with opportunities for career advancement and mentorship. Contact the PI for prestigious fellowship opportunities.
Our research focuses on elucidating molecular mechanisms governing cell division and intercellular communication, crucial for understanding disease processes like cancer. We study mitotic regulation, cytokinesis, and tunneling nanotubes using multidisciplinary approaches including microscopy, biochemistry, and model organisms like C. elegans and zebrafish.
Selected Publications
aha S, Verma R, Kumar C, Kumar B, Dey A, Surjit M, Mylavarapu SVS, and Maiti TK* (2021). Proteomic analysis reveals USP7 as a novel regulator of palmitic acid-induced hepatocellular carcinoma cell death. Cell Death and Disease, Jun 22; 13(6):563. doi: 10.1038/s41419-022-05003-4.
Kumari A, Kumar C, Pergu R, Mahale SP, Kumar M, and Mylavarapu SVS* (2021). Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions. Journal of Cell Biology, 220 (12): e202005184. doi:10.1083/jcb.20200518.
Srinivasan B, Samaddar S, Mylavarapu SVS, Clement JP and Banerjee S* (2021). Homeostatic scaling is driven by a translation-dependent degradation axis that recruits miRISC remodeling. PLoS Biology, https://doi.org/10.1371/journal.pbio.3001432.
Sharma A, Dagar S, Mylavarapu SVS (2020). Transgelin-2 and phosphoregulation of the LIC2 subunit of dynein regulate mitotic spindle orientation Journal of Cell Science, 133 (12):jcs239673. doi: 10.1242/jcs.239673. PMID: 32467330.
Sudha R, Anantharaman L, Sivaram MVS, Lohiya NK, Gupta RB, Roy RP. (2004) Linkage of interactions in sickle hemoglobin fiber assembly: inhibitory effect emanating from mutations in the AB region of the alpha-chain is annulled by a mutation at its EF corner. J Biol Chem 279 (19):20018.