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Profile
Dr. Subhra Chakraborty, Director, National Institute of Plant Genome Research obtained her Ph.D in Plant Molecular Biology from Jawaharlal Nehru University. After a brief career as Research Scientist at the Centre for Plant Molecular Biology, Jawaharlal Nehru University, she joined National Institute for Plant Genome Research as one of the founding faculty and has been continuously ascending the ranks ever since. She worked as Visiting Scientist at the Yale University, USA. Trained as a molecular biologist and biotechnologist, she got interested in protein science and was instrumental in initiating and establishing Plant Proteomics and Translational Genomics research in India. The major research interest of her laboratory is focused in the area of Nutritional Genomics, Plant Immunity, Multi-host resistance, Proteomics and Plant Biotechnology. The targeted research in the field has direct implications in plant and human health and vital to food and nutritional security.
Current Focus Areas
Nutritional genomics and proteomics with a focus on protein nutrition, antinutrient (oxalic acid) management
Translational remodeling and protein network changes involved in multi-host resistance and nutrient signaling.
Development of comparative organellar and organ-specific proteome maps in crop plants that not only provided mechanistic understanding underlying nutrient- and stress-responses, but help identifying key regulatory biomarkers those served as a valuable resource for translational research.
Fungal effector biology and pathogen-host interaction
Germplasm Charcterization program for accelerated breeding of climate resilience verities by identifying superior genes/alleles governing traits of agronomic importance and promising trait-specific accessions (donors) contrasting for superior yield component and biotic stress tolerance, and nutritional quality traits
Cross-species immune signaling that controls surveillance mechanism of innate immunity in multi-host fungal pathogenesis
Development of value added genetically-tailored climate-resilient crops using gene editing and genetic engineering for better human and plant health and food and nutrition security.
Selected Publications
1. Narula K, Elagamey E, Abdellatef MAE, Sinha S, Ghosh S, Chakraborty N and Chakraborty S (2020) Chitosan-triggered immunity to Fusarium in chickpea is associated with changes in the plant extracellular matrix architecture, stomatal closure and remodelling of the plant metabolome and proteome. Plant J. 103: 561-583.
2. Nag, P., Aggarwal, P.R., Ghosh, S., Narula, K., Tayal, R., Maheshwari, N., Chakrabortyand, N. and Chakraborty, S. (2017) Interplay of neuronal and non-neuronal genes regulates intestinal DAF-16-mediated immune response during Fusarium infection of Caenorhabditis elegans. Cell Death Discov. 3, e17073
3. Chakraborty, N., Ghosh, R., Ghosh, S., Narula, K., Tayal, R., Datta, A., and Chakraborty, S. (2013) Reduction of oxalate levels in tomato fruit and consequent metabolic remodeling following overexpression of a fungal oxalate decarboxylase. Plant Physiol. 162: 364-378.
4. Chakraborty, S., Chakraborty, N., Agrawal, L., Ghosh, S., Narula, K., Shekhar, S., Naik, PS., Pande, P.C., Chakraborti, S.K. and Datta, A. (2010) Next-generation protein-rich potato expressing the seed protein gene AmA1 is a result of proteome rebalancing in transgenic tuber. Proc. Natl. Acad. Sci. USA 107: 17533-17538.
5. Choudhary, M.K., Basu, D., Datta, A., Chakraborty, N. and Chakraborty, S. (2009) Dehydration-responsive nuclear proteome of rice (Oryza sativa L.) illustrates protein network, novel regulators of cellular adaptation and evolutionary perspect. Mol. Cell. Proteomics 8: 1579-1598