Profile
After completing my B. Pharmacy in 2005, I chose to pursue M. Tech in Bioinformatics at IIIT Allahabad to enhance my computing and informatics skills. My goal was to delve into big-data genomics questions and delve deeper into computer-aided drug designing. During my research stints at NBRI Lucknow and NABI Mohali, I focused on developing supercomputing-enabled software and databases to advance plant genomics research. I collaborated with various groups interested in enhancing crop nutrition. During my Ph.D. at ZiemertLab, University of Tuebingen, Germany from October 2018 to September 2021, I developed new software tools and databases to expedite natural product discovery via metagenomics big-data. Now back at NABI, I aim to apply my pharmacy and computational biology expertise to accelerate novel natural product discovery and design nutritious food crops. Outside work, I find joy in playing badminton, practicing yoga, and exploring new destinations.
Current Focus Areas
Our current focus lies in advancing algorithms, databases, and tools for mining multi-omics data. We're accelerating gene discovery of cereals and fruits to enhance nutrition.
Leveraging open-source software on our 'Tera-scale Supercomputing Cluster', we develop custom solutions for integrative analysis, bridging gaps in available tools to decipher complex pathways and understand the genome's language.
Metagenome mining to explore novel regions of natural product chemical space
De-Novo Smart Protein Design using Artificial Intelligence tools
Selected Publications
Chevrette, M. G., Gavrilidou, A., Mantri, S., Selem-Mojica, N., Ziemert, N., & Barona-Gómez, F. (2021). The confluence of big data and evolutionary genome mining for the discovery of natural products. Natural Product Reports, 38(11), 2024-2040.
Mantri, S.S., Negri, T., Sales-Ortells, H., Angelov, A., Peter, S., Neidhardt, H., Oelmann, Y. and Ziemert, N., (2021). Metagenomic sequencing of multiple soil horizons and sites in close vicinity revealed novel secondary metabolite diversity. Msystems, 6(5), pp.e01018-21.
Elfeki, M., Mantri, S., Clark, C. M., Green, S. J., Ziemert, N., & Murphy, B. T. (2021). Evaluating the Distribution of Bacterial Natural Product Biosynthetic Genes across Lake Huron Sediment. ACS chemical biology, 16(11), 2623-2631.
Yadav, B., Singh, D., Mantri, S. and Rishi, V., 2024. WGBS of Differentiating Adipocytes Reveals Variations in DMRs and Context-Dependent Gene Expression. bioRxiv, pp.2024-03.
Gurjar A.K.S, Panwar A.S, Gupta R. and Mantri S. (2016). PmiRExAt: Plant miRNA Expression Atlas Database and web applications. Database 2016; 2016 baw060. doi: 10.1093/database/baw060