Profile
A protein chemist who works at the interface of chemistry and biology, creates synergy in protein engineering by combining recombinant expression, enzymatic ligation and peptide synthesis.
Current Focus Areas
Protein engineering, Peptide ligation and protein Semi-synthesis
Selected Publications
Das S, Pawale VS, Dadireddy V, Singh AK, Ramakumar S and Roy RP (2017) Structure and specificity of a new class of Ca2+ independent housekeeping sortase from Streptomyces avermitilis provides insights into its non-canonical substrate preference. J Biol Chem 292:7244-57.
Dasgupta S, Samantaray S, Sahal D and Roy RP (2011) Isopeptide ligation catalyzed by quintessential Sortase A. J Biol Chem 286: 23996-24006.
Samantaray S, Marathe U, Dasgupta S, Nandicoori VK, Roy RP (2008) Peptide-sugar ligation catalyzed by transpeptidase Sortase. J Am Chem Soc 130: 2133-34.
Biswas T, Misra A, Das S, Yadav P, Ramakumar S, Roy RP (2020) Interrogation of 3D-swapped structure and functional attributes of quintessential Sortase A from Streptococcus pneumoniae. Biochem J 477: 4711-28.
Shukla S, Murmu, S, Mora T, Dhanasekaran, K, Roy RP (2024) Unravelling HDAC selectivity for erasing acetyl mark on Lys-5 of Histone H2B. Chembiochem, doi: 10.1002/cbic.202300875.