Profile
Recent studies suggested a link between obesity and gut microflora. Proinflammatory “Lipopolysaccharide (LPS)” originating from Gram-negative bacteria and other bacterial metabolites translocate to the circulation causing low-grade inflammation (endotoxemia) associated with obesity. Our research goal is to develop functional foods that could beneficially modulate gut microflora and protect from inflammation underlying obesity and metabolic syndrome. Our Research is focused on 1. Understanding the role of cereals and millets and their bioactive ingredients (dietary fibers and other phytochemicals) in mitigating life style associated disorders. 2. Evaluation of probiotics and prebiotic for thier protective role under gut inflammatory conditions. We employ diet-induced obese rodent models, nutrigenomic and metagenomic approach in our studies.
Current Focus Areas
Gut Microbiome Modulation for Overcoming Lifestyle Diseases
Selected Publications
Matta T, Bhatia R, Joshi SR, Bishnoi M, Chopra K, Kondepudi KK†. (2024). GABA synthesizing lactic acid bacteria and genomic analysis of Levilactobacillus brevis LAB6. 3 Biotech. 14(3):62.
Maurya R, Shandilya C, Raina N, Rawat A, Devi K, Bhadada SK, Bishnoi M, Kondepudi KK†. (2024). Effect of Millet Polyphenol-Rich Extracts on Human Fecal Bacteria and Dextran Sulfate Sodium-Induced Human Intestinal Epithelial Cell Derangements. Food Biotech., 38 (1), 42-63. (IF: 1.8)
Sharma S, Bhatia R, Devi K, Rawat A, Singh S, Bhadada SK, Bishnoi M, Sharma SS, Kondepudi KK†. (2023). A synbiotic combination of Bifidobacterium longum Bif10 and Bifidobacterium breve Bif11, isomaltooligosaccharides and finger millet arabinoxylan prevents dextran sodium sulphate induced ulcerative colitis in mice. Int J Biol Macromol., 231: 123326. (IF: 8.2)
Devi K, Kumar V, Kumar V, Mahajan N, Kaur J, Sharma S, Kumar A, Khan R, Bishnoi M†, Kondepudi KK†. (2023). Modified cereal bran (MCB) from finger millet, kodo millet, and rice bran prevents high-fat diet-induced metabolic derangements. Food Funct., 14: 1459-1475. (IF: 6.1).
Singh S, Bhatia R, Khare P, Sharma S, Rajarammohan S, Bishnoi M, Bhadada SK, Shyam SS, Kaur J†, Kondepudi KK†. (2020). Anti-inflammatory Bifidobacterium strains prevent Dextran Sodium Sulfate induced colitis and associated gut microbial dysbiosis in mice. Sci Rep., 10:18597 (IF: 4.996)