.JPG)
Profile
Our lab focusses on identifying genes and gene panels potentially useful in earlier detection, progression, or longitudinal monitoring of tumors in breast cancer. We work on two aspects- one explores the establishment and utility of extracellular vesicle (EV) contents and cell free DNA methylation profiles in detecting or monitoring disease and the other involves basic biology of novel cancer related genes. Basic projects involve 1) characterizing cancer related long non-coding RNAs from patient derived inhouse transcriptomic datasets 2) mapping gene regulatory networks specified by the epigenetic enzyme JMJD6, and its choice of DNA binding partners in enunciating cancer favoring and endocrine therapy resistance pathways.
Current Focus Areas
I) JMJD6 and its binding partners
II) Liquid biopsy approaches for early detection and/or monitoring breast cancer
III) Mapping mechanisms of Endocrine therapy resistance
IV) Non-coding RNA biology
Selected Publications
Das P, Gupta A, Desai KV. JMJD6 orchestrates a transcriptional program in favor of endocrine resistance in ER+ breast cancer cells. Front Endocrinol. Nov 7, 2022: 13
Biswas A, Mukherjee G, Kondaiah P, Desai KV. Both EZH2 and JMJD6 regulate cell cycle genes in breast cancer. BMC Cancer. 2020 Nov 27;20(1):1159.
Haque MM and Desai KV. Pathways to Endocrine Therapy Resistance in Breast Cancer. Front. Endocrinol. 2019 10:573.
Biswas A, Shettar A, Mukherjee G, Kondaiah P, Desai KV. JMJD6 induces HOTAIR, an oncogenic lincRNA, by physically interacting with its proximal promoter. Biochem J. 2018 Jan 15;475(1):355-371
Biswas, A. and Desai, K.V. The LncRNA HOTAIR-expression, regulation and function in cancer Nucleus 2017 60: 155