Profile
Dr. Chittur V Srikanth is a distinguished Professor with a PhD earned in 2005 from the Institute of Microbial Technology. Following this, he conducted postdoctoral research at Harvard Medical School, USA, and the University of Massachusetts Medical School, USA. With expertise in microbial technology and medical research, Dr. Srikanth contributes significantly to advancing knowledge in his field. His research interests span various aspects of microbiology, immunology, and medical science. As a Professor, he is committed to mentoring the next generation of scientists and fostering a collaborative research environment. Dr. Srikanth's scholarly contributions and academic leadership have garnered recognition, and he continues to make significant contributions to scientific inquiry and innovation. Through his dedication to research and education, he plays a vital role in shaping the future of microbiological and medical research.
Current Focus Areas
Our lab investigates inflammation in gastrointestinal infections and autoimmune disorders, focusing on Salmonella Typhimurium pathogenesis, gut microbiota, autoimmune disorders, and gastrointestinal cancers. Utilizing advanced microbiology and molecular biology tools, including PTM pathways, we aim to develop therapeutic solutions for bacterial infections and autoimmune disorders.
Selected Publications
Chandrasekhar H, Mohapatra G, Kajal K, Singh M, Walia K, Rana S, Kaur N, Sharma S, Tuli A, Das P, Srikanth CV. SifA SUMOylation governs Salmonella Typhimurium intracellular survival via modulation of lysosomal function. PLoS Pathog. 2023 Sep 29;19(9):e1011686.
Mehrotra T, Konar D, Pragasam AK, Kumar S, Jana P, Babele P, Paul D, Purohit A, Tanwar S, Bakshi S, Das S, Verma J, Talukdar D, Narendrakumar L, Kothidar A, Karmakar SP, Chaudhuri S, Pal S, Jain K, Srikanth CV, Sankar MJ, Atmakuri K, Agarwal R, Gaind R, Ballal M, Kammili N, Bhadra RK, Ramamurthy T, Nair GB, Das B. Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305465120.
Gaur P, Rajendran Y, Srivastava B, Markandey M, Fishbain-Yoskovitz V, Mohapatra G, Suhail A, Chaudhary S, Tyagi S, Yadav SC, Pandey AK, Merbl Y, Bajaj A, Ahuja V, Srikanth C. Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis. Elife. 2024 Apr 9;12:RP89776.
Johnson EE, Srikanth CV, Sandgren A, Harrington L, Trebicka E, Wang L, Borregaard N, Murray M, Cherayil BJ. Siderocalin inhibits the intracellular replication of Mycobacterium tuberculosis in macrophages. FEMS Immunol Med Microbiol. 2010 Feb;58(1):138-45.
Zhang MY, Bourbouloux A, Cagnac O, Srikanth CV, Rentsch D, Bachhawat AK, Delrot S. A novel family of transporters mediating the transport of glutathione derivatives in plants. Plant Physiol. 2004 Jan;134(1):482-91.