Profile
Dr. Manjula Kalia is an accomplished Associate Professor with a PhD earned in 1998 from the National Institute of Immunology, New Delhi. Following this, she pursued postdoctoral research at the University of Calgary, Canada, and held prestigious positions including Visiting Fellow & DST-Fast Track Scientist at NCBS, Bangalore, and DBT-IYBA Scientist at ICGEB, New Delhi. She further enriched her career as a Research Scientist D/E at VIDRC, THSTI, Faridabad. Dr. Kalia's research expertise spans immunology and related fields, focusing on diverse aspects of immune system regulation, host-pathogen interactions, and vaccine development. Through her extensive academic journey and contributions to research, she has garnered recognition and made significant strides in advancing scientific knowledge. Dr. Kalia's dedication to research and academic excellence continues to inspire her peers and students alike.
Current Focus Areas
Our research delves into the intricate interactions between Flaviviruses (JEV and Dengue virus) and host cellular mechanisms, focusing on membrane trafficking, autophagy, and ER-associated degradation pathways. We aim to elucidate virus-host interactions, identify drug targets, and enhance vaccine efficacy to combat Flavivirus infections.
Interactions of Flaviviruses with host cellular mechanisms and implications for pathogenesis Host-pathogen interaction is a series of complex and intertwined cellular and signalling events that determine disease outcome. Understanding these interactions is crucial for identification and development of therapies, vaccines and anti-viral drugs.
Selected Publications
KB, Kalia M (2022). Human Guanylate-binding Protein 1 positively regulates Japanese encephalitis virus replication in an interferon gamma primed environment. Front Cell Infect Microbiol 2022 May 19;12:832057. doi: 10.3389/fcimb.2022.832057. eCollection
Agarwal A, Alam MF, Basu B, Pattanayak S, Asthana S, Syed GH, Kalia M, Vrati S (2022). Japanese Encephalitis Virus NS4A protein interacts woth PTEN-Induced Kinase 1 (PINK1) and promotes mitophagy in infected cells. Microbiology Spectrum. 2022 May 23:e0083022. doi: 10.1128/spectrum.00830-22.
Shailendra Chauhan, Deepak Kumar Rathore, Shilpa Sachan, Sebastien Lacroix-Desmazes, Nimesh Gupta, Amit Awasthi, Sudhanshu Vrati and Manjula Kalia (2021) “Japanese Encephalitis Virus Infected Human Monocyte-Derived Dendritic Cells Activate a Transcriptional Network Leading to an Antiviral Inflammatory Response” Frontiers in Immunology 12: 638694.doi: 10.3389/fimmu.2021.638694
Nath P, Chauhan NR, Jena KK, Datey A, Kumar ND, Mehto S, De S, Nayak TK, Priyadarsini S, Rout K, Bal R, Murmu KC, Kalia M, Patnaik S, Prasad P, Reggiori F, Chattopadhyay S, Chauhan S. Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses (2021). EMBO Rep. 2021 Nov 4;22(11): e52948. doi: 10.15252/embr.202152948. Epub 2021 Sep 1.
M. Awasthi-Kalia, K.V. Bhat and R.K. Anand. (2002) “Genetic characterization of Mus musculus and related forms from India”. Experimental Animals 51: No 1. 103-107